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Table 2 Association between 10-year CVD risk and i) initiations or ii) discontinuations of ABC in the pre- and post-March 2008 periods (factors included in adjusted analyses are listed in the Methods section)

From: Is there continued evidence for an association between abacavir usage and myocardial infarction risk in individuals with HIV? A cohort collaboration

Framingham risk group ABC initiations/total ART initiations Percentage (95 % CI) aOR (95 % CI)
i) Initiations of ABC
 Pre-March 2008
  Low/unknown 1,251/9,213 13.6 (12.8, 14.3) 1
  Moderate/high 111/648 17.1 (13.9, 20.3) 1.14 (0.90, 1.44)
 Post-March 2008
  Low/unknown 326/4,282 7.6 (6.8, 8.4) 1
  Moderate/high 33/622 5.3 (3.5, 7.1) 0.74 (0.48, 1.13)
  Interaction P value    0.007
ii) Discontinuations of ABC Discontinuations/PYRS Rate/100 PYRS (95 % CI) aRR (95 % CI)
Suppressed/low viral load
 Pre-March 2008
  Low/unknown 2,045/16,506 12.4 (11.9, 12.9) 1
  Moderate/high 562/5,465 10.3 (9.4, 11.1) 1.04 (0.93, 1.16)
 Post-March 2008
  Low/unknown 1,403/13,950 10.1 (9.5, 10.6) 1
  Moderate/high 880/6,560 13.4 (12.5, 14.3) 1.49 (1.34, 1.65)
  Interaction P value    0.0001
Non-suppressed viral load
 Pre-March 2008
  Low/unknown 2,966/7,766 38.2 (36.8, 39.6) 1
  Moderate/high 662/2,041 32.4 (29.9, 34.9) 0.99 (0.90, 1.09)
 Post-March 2008
  Low/unknown 622/2,297 27.1 (25.0, 29.2) 1
  Moderate/high 236/921 25.6 (22.4, 28.9) 1.23 (1.02, 1.48)
  Interaction P value    0.07
  1. ABC abacavir, aOR adjusted odds ratio, aRR adjusted rate ratio, ART antiretroviral therapy, CI confidence interval, CVD cardiovascular disease, PYRS person-years