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Table 4 Results from sensitivity analyses. i) Adjusted rate ratio for the association between MI and ABC, stratified by calendar period and CVD risk, and ii) adjusted rate ratio for the association between MI and ABC after further adjustment for factors that potentially lie on the causal pathway (see Methods section)

From: Is there continued evidence for an association between abacavir usage and myocardial infarction risk in individuals with HIV? A cohort collaboration

  Pre-March 2008 Post-March 2008 P value (interaction between ABC use and calendar period)
Sensitivity analysis MI event rate (95 % CI)/100 PYRS aRR (95 % CI) MI event rate (95 % CI)/100 PYRS aRR (95 % CI)
i) Stratified by Framingham risk      
 Low 0.14 (0.12, 0.16) 2.48 (1.74, 3.52) 0.08 (0.06, 0.09) 2.11 (1.12, 3.98) 0.78
 Moderate 0.69 (0.59, 0.80) 1.69 (1.21, 2.35) 0.32 (0.26, 0.39) 2.19 (1.25, 3.84) 0.68
 High 1.80 (1.56, 2.05) 1.51(1.12, 2.05) 0.74 (0.58, 0.90) 1.65 (0.93, 2.92) 0.16
ii) Further adjustment for factors on causal pathway n/a 1.88 (1.55, 2.28) n/a 2.03 (1.46, 2.84) 0.61
  1. ABC abacavir, aRR adjusted rate ratio, CI confidence interval, CVD cardiovascular disease, MI myocardial infarction