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Table 4 Results from sensitivity analyses. i) Adjusted rate ratio for the association between MI and ABC, stratified by calendar period and CVD risk, and ii) adjusted rate ratio for the association between MI and ABC after further adjustment for factors that potentially lie on the causal pathway (see Methods section)

From: Is there continued evidence for an association between abacavir usage and myocardial infarction risk in individuals with HIV? A cohort collaboration

 

Pre-March 2008

Post-March 2008

P value (interaction between ABC use and calendar period)

Sensitivity analysis

MI event rate (95 % CI)/100 PYRS

aRR (95 % CI)

MI event rate (95 % CI)/100 PYRS

aRR (95 % CI)

i) Stratified by Framingham risk

     

 Low

0.14 (0.12, 0.16)

2.48 (1.74, 3.52)

0.08 (0.06, 0.09)

2.11 (1.12, 3.98)

0.78

 Moderate

0.69 (0.59, 0.80)

1.69 (1.21, 2.35)

0.32 (0.26, 0.39)

2.19 (1.25, 3.84)

0.68

 High

1.80 (1.56, 2.05)

1.51(1.12, 2.05)

0.74 (0.58, 0.90)

1.65 (0.93, 2.92)

0.16

ii) Further adjustment for factors on causal pathway

n/a

1.88 (1.55, 2.28)

n/a

2.03 (1.46, 2.84)

0.61

  1. ABC abacavir, aRR adjusted rate ratio, CI confidence interval, CVD cardiovascular disease, MI myocardial infarction