Main exposure/potential confounders/a priori confounders | Overall cohort | Missing 12-month outcome | Unfavourable 12-month outcome | Univariate regressiona | ||||
---|---|---|---|---|---|---|---|---|
No. | Col. % | No. | Row % | No. | Row % | OR (95 % CI) | ||
Overall | 48,838 | 100.0 | 1,468 | 3.0 | 6,777 | 13.9 | – | |
Clinician caseloadb | ||||||||
10+ | 24,092 | 49.3 | 401 | 1.7 | 3,057 | 12.7 | P <0.001 | |
<10 | 16,803 | 34.4 | 767 | 4.6 | 2,518 | 15.0 | 1.20 (1.10–1.30) | |
Missing | 7,943 | 16.3 | 300 | 3.8 | 1,202 | 15.1 | – | |
Notification date | ||||||||
Post-toolkit | 39,264 | 80.4 | 920 | 2.3 | 5,283 | 13.5 | P <0.001 | |
Pre-toolkit | 9,574 | 19.6 | 548 | 5.7 | 1,494 | 15.6 | 1.28 (1.19–1.38) | |
Missing | 0 | 0.0 | 0 | – | 0 | – | – | |
Location | ||||||||
Outside London | 28,212 | 57.8 | 1,338 | 4.7 | 4,069 | 14.4 | P <0.001 | |
Inside London | 20,618 | 42.2 | 130 | 0.6 | 2,704 | 13.1 | 0.78 (0.70–0.86) | |
Missing | 8 | 0.0 | 0 | 0.0 | 4 | 50.0 | – | |
Sex | ||||||||
Male | 26,910 | 55.1 | 829 | 3.1 | 4,051 | 15.1 | P <0.001 | |
Female | 21,777 | 44.6 | 630 | 2.9 | 2,700 | 12.4 | 0.80 (0.76–0.85) | |
Missing | 151 | 0.3 | 9 | 6.0 | 26 | 17.2 | – | |
Age, years | ||||||||
<20 | 4,987 | 10.2 | 128 | 2.6 | 477 | 9.6 | 0.66 (0.58-0.75) | |
20–39 | 23,987 | 49.1 | 677 | 2.8 | 3,334 | 13.9 | P <0.001 | |
40–64 | 13,534 | 27.7 | 400 | 3.0 | 1,749 | 12.9 | 0.91 (0.85–0.97) | |
65+ | 6,325 | 13.0 | 263 | 4.2 | 1,215 | 19.2 | 1.42 (1.31–1.54) | |
Missing | 5 | 0.0 | 0 | 0.0 | 2 | 40.0 | – | |
Ethnic group | ||||||||
White | 9,313 | 19.1 | 401 | 4.3 | 1,580 | 17.0 | P <0.001 | |
Black African | 9,666 | 19.8 | 243 | 2.5 | 1,176 | 12.2 | 0.67 (0.61–0.74) | |
Black other | 1,473 | 3.0 | 20 | 1.4 | 213 | 14.5 | 0.85 (0.71–1.01) | |
Indian subcontinent | 21,082 | 43.2 | 486 | 2.3 | 2,753 | 13.1 | 0.74 (0.68–0.80) | |
Other | 5,662 | 11.6 | 131 | 2.3 | 746 | 13.2 | 0.74 (0.67–0.83) | |
Missing | 1,642 | 3.4 | 187 | 11.4 | 309 | 18.8 | – | |
UK born | ||||||||
No | 33,946 | 69.5 | 777 | 2.3 | 4,517 | 13.3 | P <0.001 | |
Yes | 11,946 | 24.5 | 397 | 3.3 | 1,742 | 14.6 | 1.12 (1.05–1.20) | |
Missing | 2,946 | 6.0 | 294 | 10.0 | 518 | 17.6 | – | |
Site of diseasec | ||||||||
Extrapulmonary only | 21,681 | 44.4 | 543 | 2.5 | 2,662 | 12.3 | P <0.001 | |
Pulmonary smear negative/unknown | 17,483 | 35.8 | 578 | 3.3 | 2,441 | 14.0 | 1.18 (1.10–1.26) | |
Pulmonary smear positive | 9,399 | 19.2 | 313 | 3.3 | 1,623 | 17.3 | 1.53 (1.41–1.65) | |
Missing | 275 | 0.6 | 34 | 12.4 | 51 | 18.5 | – | |
Drug sensitivity | ||||||||
Sensitive | 26,955 | 55.2 | 782 | 2.9 | 3,607 | 13.4 | P <0.001 | |
Resistant to INH, EMB, or PZA | 1,744 | 3.6 | 53 | 3.0 | 756 | 43.3 | 5.63 (5.01–6.32) | |
Not linked to a culture | 19,865 | 40.7 | 627 | 3.2 | 2,364 | 11.9 | 0.86 (0.80–0.91) | |
Missing | 274 | 0.6 | 6 | 2.2 | 50 | 18.2 | – | |
Previous diagnosis | ||||||||
No | 39,767 | 81.4 | 1,006 | 2.5 | 5,227 | 13.1 | P <0.001 | |
Yes | 2,941 | 6.0 | 96 | 3.3 | 494 | 16.8 | 1.35 (1.20–1.51) | |
Missing | 6,130 | 12.6 | 366 | 6.0 | 1,056 | 17.2 | – | |
Social risk factorsd | ||||||||
No or unknown | 47,048 | 96.3 | 1,394 | 3.0 | 6,352 | 13.5 | P <0.001 | |
One or more previous | 829 | 1.7 | 19 | 2.3 | 144 | 17.4 | 1.42 (1.17–1.73) | |
One or more current | 961 | 2.0 | 55 | 5.7 | 281 | 29.2 | 2.75 (2.34–3.23) | |
Shared clinical management | ||||||||
No or unknown | 48,562 | 99.4 | 1,457 | 3.0 | 6,721 | 13.8 | P = 0.02 | |
Yes | 276 | 0.6 | 11 | 4.0 | 56 | 20.3 | 1.45 (1.06–1.98) |