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Table 4 Odds ratios (ORs) for high- vs low-grade prostate cancer by pubertal development genetic risk score tertiles in the ProtecT study

From: Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort

Genetic score tertiles OR 95 % CI P value
T1 Reference   0.003
T2 0.79 0.58–1.07  
T3 0.57 0.41–0.79  
  1. High-grade prostate cancer = Gleason ≥7
  2. Low-grade prostate cancer = Gleason ≤6
  3. OR adjusted by age, recruitment centre and 10 principal components for population structure
  4. n = 1,135
  5. CI Confidence intervals