Fig. 3

Pathway analysis, using gene expression data from unstimulated PBMC, in the two clusters of infants. Samples from the primary cohort were analyzed. A one group versus all other groups analysis approach was used to identify genes differentially expressed in each of the four groups, when compared to a pool of the three other groups (Additional file 4: Table S3). Then, genes were ranked according to the moderated t test and GSEA used to identify pathways enriched in each of the four groups. Finally, pathways uniquely and commonly expressed within each group were identified, using a FDR adjusted p value cutoff of < 0.05. The Venn diagram (a) shows both shared and unique gene sets, which are identified in (b). Gene sets are sized by normalized enrichment score (NES)