Fig. 2

Identification of core gene sets differentially expressed in spontaneous term labor and preterm labor (PTL) models. (a) Venn diagram representing overlap between differentially expressed genes (DEGs) as detected in term labor (blue), and RU486-induced (gray) and lipopolysaccharide (LPS)-induced (yellow) PTL models. Process Network Analysis (Metacore®) was performed on the core set, including those genes similarly changing in all models of parturition (b), on genes changing only in the term labor model (c), genes exclusively changing with RU486 treatment (d), and on genes exclusively changing following LPS treatment (e). Bar length indicates significance and is equal to the negative logarithm of enrichment P value. A P value cut-off less than 0.05 (−log₁₀P > 1.3) was applied and is indicated by the dashed line