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Fig. 5 | BMC Medicine

Fig. 5

From: Modeling hormonal and inflammatory contributions to preterm and term labor using uterine temporal transcriptomics

Fig. 5

Comparison of murine and human myometrial transcriptome datasets. a Venn diagram depicting 357 orthologs significantly changing in the myometrium of murine models of term gestation, RU486-induced, and LPS-induced preterm labor (PTL), and at the onset of spontaneous labor in human. The total number of differentially expressed genes identified in murine models and in human samples is reported in square brackets. b A total of 357 orthologs were used to perform orthogonal signal correction-partial least squares (OSC-PLS) analysis to test for correlation between murine and human myometrium transcriptome changes associated with activation of contractions and labor. Murine gene expression changes associated with each model of gestation were used as a training set and gene changes characterizing the onset of spontaneous human term labor were tested against each model. r Pearson’s correlation coefficient. Correlation between training set and test sets is considered significant if P < 0.05. c Hierarchical clustering of loadings values from OSC-PLS models allowed the identification of eight clusters (color-coded side bar) of genes with similar expression patterns throughout murine gestation and in human myometrium samples prior to and following the onset of spontaneous term labor. d The gene read counts (normalized to the maximum value) belonging to each cluster are displayed separately as gene expression patterns throughout term gestation (blue), RU486-induced (gray), and lipopolysaccharide (LPS)-induced PTL (yellow) and during term human labor (black). e Top networks relative to each cluster identified by Process Network Analysis. Gene patterns associated with each cluster are summarized by the color-coded arrows represented in the first column of the table (blue, term gestation; gray, RU486 model; yellow, LPS model). Enrichment is considered significant if P < 0.05

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