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Table 3 Mortality outcomes

From: Maternal antenatal multiple micronutrient supplementation for long-term health benefits in children: a systematic review and meta-analysis

Location

Follow-up study

Deaths in control groupa

Livebirths in control group

Deaths in intervention groupa

Livebirths in MMN group

Mortality differencea

MMN – control, per 1000 livebirths (95 % CI)

Bangladesh, JiVitA

West et al. [26]

764

625 neonatal

139 at 29–180 days

14,142

741

626 neonatal

115 at 29–180 days

14,374

–2.5 (–8.1 to 3.1)b

Bangladesh, MINIMat

Persson et al. [27]

33

23 neonatal

10 post-neonatal to 5 years

612

34

25 neonatal

9 post-neonatal to 5 years

595

3.2 (–22.6 to 29.0)

Burkina Faso

Roberfroid et al. [35]

45

7 neonatal

38 post-neonatal to 30 months

644

55

11 neonatal

44 post-neonatal to 30 months

650

14.7 (–14.3 to 43.8)

Chinac

Wang et al. [41]

16

16 neonatal

0 in children born in 2004

1499

20

18 neonatal

2 in children born in 2004

1469

6.10 (–3.9 to 17.3)b

Guinea Bissau

Andersen et al. [36]

57

25 neonatal

9 at 29–91 days

10 at 92–365 days

13 at 366–730 days

519

65

29 neonatal

6 at 29–91 days

21 at 92–365 days

9 at 366–730 days

528

13.3 (–25.8 to 52.4)

Indonesiac

Prado et al. [37]

580 infant

17 in subsample

14,053

490 infant

12 in subsample

14,373

–13.2 (–33.4 to 7.1)b

Mexicoc

Ramakrishnan et al. [38]

7

6 early deaths

1 in control group of childhood randomisation

460

4

4 early deaths

456

–10.30 (–29.30 to 6.60)

Nepal Janakpur

Devakumar et al. [39]

22

12 neonatal

6 post-neonatal

4 at 1–8 years

564

23

17 neonatal

4 post-neonatal

2 at 1–8 years

567

1.6 (–21.2 to 24.3)

Nepal Sarlahi

Christian et al. [40]

54

34 before 91 days

20 at 91 days to 7 years

773

81

52 before 91 days

29 at 91 days to 7 years

872

23.0 (–5.2 to 51.3)b

  1. aMortality figures given for the most recent follow-up. In the case of the Bangladesh MINIMat study, this was the trial paper
  2. bThe analysis accounts for clustering in relevant trials. Design effects of 1.15, 1.20 and 1.20 were predicted in the Bangladesh JiVitA, Indonesia and Nepal Sarlahi trials, respectively [26, 29, 34]; the China trial did not report a figure and we used a design effect of 1.20
  3. cThe follow-up report described a subgroup of children; confidence intervals were created using a simulation approach, as described in more detail in the methods section