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Table 2 Primary outcomes at 6 and 12 months in control and intervention groups

From: The CARE Plus study – a whole-system intervention to improve quality of life of primary care patients with multimorbidity in areas of high socioeconomic deprivation: exploratory cluster randomised controlled trial and cost-utility analysis

Outcomes Change from baseline Adjusteda mean difference (95 % CI) Effect size (95 % CI) p value
Usual care CARE Plus
Primary outcomes:
 6 months
  EQ5D-5 L −0.08 (0.27) 0.04 (0.25) 0.13 (0.01, 0.25) 0.38 (0.00, 0.75) 0.039
  W-BQ12 General Well-being −1.3 (5.1) −0.2 (6.5) 0.70 (−2.45, 3.85) 0.08 (−0.28, 0.44) 0.66
  W-BQ12 Negative Well-being 1.0 (2.8) 0.0 (2.9) −0.69 (−1.63, 0.24) 0.18 (−0.06, 0.42) 0.14
  W-BQ12 Energy 0.7 (2.8) 0.2 (2.7) −0.42 (−1.85, 1.01) −0.15 (−0.65, 0.36) 0.56
  W-BQ12 Positive Well-being −0.9 (2.8) −0.5 (3.5) 0.66 (−0.31, 1.64) 0.18 (−0.09, 0.46) 0.18
 12 months
  EQ5D-5 L −0.02 (0.28) 0.02 (0.26) 0.06 (−0.02, 0.14) 0.14 (−0.10, 0.39) 0.15
  W-BQ12 General Well-being −1.6 (5.6) 0.4 (6.8) 1.99 (−0.27, 4.24) 0.23 (−0.03, 0.49) 0.083
  W-BQ12 Negative Well-being 1.2 (2.8) −0.2 (2.5) −1.30 (−2.16, −0.43) 0.33 (0.11, 0.55) 0.0036
  W-BQ12 Energy 0.6 (2.4) 0.6 (2.9) 0.31 (−0.55, 1.17) 0.11 (−0.20, 0.42) 0.47
  W-BQ12 Positive Well-being −0.8 (3.3) −0.6 (3.8) 0.57 (−0.56, 1.70) 0.16 (−0.16, 0.48) 0.32
  1. aMean differences were adjusted for baseline score, age, gender and Hospital Anxiety and Depression Scale caseness - positive effects sizes indicate a difference in favour of the intervention group.
  2. CI confidence interval