Fig. 3
From: Association between trial registration and treatment effect estimates: a meta-epidemiological study
Comparison of treatment effect estimates by trial registration. Difference in treatment effect estimates is expressed as ROR. An ROR <1 indicates larger estimates of treatment effect in trials retrospectively registered or not registered, registered after the primary completion date, not compliant with the ICMJE and not registered, respectively. * Compliance with the ICMJE requirement is defined as registration before 13 September 2005 for trials starting before July 2005 and prospective registration for trials starting in July 2005 or after [2]. ICMJE International Committee of Medical Journal Editors