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Table 1 In vivo animal studies presenting the effect of osteogenic growth peptide (OGP) on bone and bone healing

From: The role of peptides in bone healing and regeneration: a systematic review

Study/Year

Model

Mode of delivery

Results

Sun et al., 1998 [89]

Tibial fracture in rabbits

IV administration

• OGP treatment accelerated fracture union

Brager et al., 2000 [85]

Femoral fracture in rats

Systematic administration of OGP (25 ng/day)

• OGP enhances proliferation and differentiation of osteogenic cells possibly through the upregulation of TGF-beta

Gabet et al., 2004 [83]

Mid-femoral fracture in rats

Systematic administration of OGP

• OGP administration resulted in enhanced bridging across fracture gap, higher volume of callus and newly formed bone

Shuqiang et al., 2008 [84]

Radial 1.5 cm segmental defect in rabbits

OGP incorporated in PLGA

• The rate of bone formation and volume were statistically significantly upregulated in experimental group

Zhao et al., 2011 [88]

Distraction osteogenesis in rabbit tibia

Systematic administration of OGP (200 ng/kg/day)

• OGP treatments resulted in greater torsional stiffness, higher chondrocyte numbers and amount of newly formed bone