From: The role of peptides in bone healing and regeneration: a systematic review
Study/Year | Model | Mode of delivery | Results |
---|---|---|---|
Sun et al., 1998 [89] | Tibial fracture in rabbits | IV administration | • OGP treatment accelerated fracture union |
Brager et al., 2000 [85] | Femoral fracture in rats | Systematic administration of OGP (25 ng/day) | • OGP enhances proliferation and differentiation of osteogenic cells possibly through the upregulation of TGF-beta |
Gabet et al., 2004 [83] | Mid-femoral fracture in rats | Systematic administration of OGP | • OGP administration resulted in enhanced bridging across fracture gap, higher volume of callus and newly formed bone |
Shuqiang et al., 2008 [84] | Radial 1.5 cm segmental defect in rabbits | OGP incorporated in PLGA | • The rate of bone formation and volume were statistically significantly upregulated in experimental group |
Zhao et al., 2011 [88] | Distraction osteogenesis in rabbit tibia | Systematic administration of OGP (200 ng/kg/day) | • OGP treatments resulted in greater torsional stiffness, higher chondrocyte numbers and amount of newly formed bone |