TY - JOUR AU - Blagosklonny, M. V. PY - 2002 DA - 2002// TI - From the war on cancer to translational oncology JO - Cancer Biol Ther VL - 1 UR - https://doi.org/10.4161/cbt.325 DO - 10.4161/cbt.325 ID - Blagosklonny2002 ER - TY - JOUR AU - George, S. AU - Desai, J. PY - 2002 DA - 2002// TI - Management of gastrointestinal stromal tumors in the era of tyrosine kinase inhibitors JO - Curr Treat Options Oncol VL - 3 UR - https://doi.org/10.1007/s11864-002-0068-2 DO - 10.1007/s11864-002-0068-2 ID - George2002 ER - TY - JOUR AU - Mulshine, J. L. AU - Jett, M. AU - Cuttitta, F. AU - Treston, A. M. AU - Quinn, K. AU - Scott, F. AU - Iwai, N. AU - Avis, I. AU - Linnoila, R. I. AU - Shaw, G. L. PY - 1993 DA - 1993// TI - Scientific basis for cancer prevention. Intermediate cancer markers JO - Cancer VL - 72 UR - https://doi.org/3.0.CO;2-T DO - 3.0.CO;2-T ID - Mulshine1993 ER - TY - JOUR AU - Demetri, G. D. PY - 1993 DA - 1993// TI - Beyond supportive care: what are the next questions in the use of hematopoietic cytokines with cytotoxic chemotherapy? JO - Blood VL - 82 ID - Demetri1993 ER - TY - JOUR AU - Geraghty, J. PY - 1996 DA - 1996// TI - Adenomatous polyposis coli and translational medicine JO - Lancet VL - 348 UR - https://doi.org/10.1016/S0140-6736(05)64535-7 DO - 10.1016/S0140-6736(05)64535-7 ID - Geraghty1996 ER - TY - JOUR AU - Doroshow, J. H. AU - Kummar, S. PY - 2014 DA - 2014// TI - Translational research in oncology--10 years of progress and future prospects JO - Nat Rev Clin Oncol VL - 11 UR - https://doi.org/10.1038/nrclinonc.2014.158 DO - 10.1038/nrclinonc.2014.158 ID - Doroshow2014 ER - TY - JOUR AU - Dizon, D. S. AU - Krilov, L. AU - Cohen, E. AU - Gangadhar, T. AU - Ganz, P. A. AU - Hensing, T. A. AU - Hunger, S. AU - Krishnamurthi, S. S. AU - Lassman, A. B. AU - Markham, M. J. AU - Mayer, E. AU - Neuss, M. AU - Pal, S. K. AU - Richardson, L. C. AU - Schilsky, R. AU - Schwartz, G. K. AU - Spriggs, D. R. AU - Villalona-Calero, M. A. AU - Villani, G. AU - Masters, G. PY - 2016 DA - 2016// TI - Clinical Cancer Advances 2016: annual report on progress against cancer from the American Society of Clinical Oncology JO - J Clin Oncol VL - 34 UR - https://doi.org/10.1200/JCO.2015.65.8427 DO - 10.1200/JCO.2015.65.8427 ID - Dizon2016 ER - TY - STD TI - Cancer Moonshot 2020. http://www.cancermoonshot2020.org/. Accessed 4 July 2016. UR - http://www.cancermoonshot2020.org/ ID - ref8 ER - TY - STD TI - Back to Earth. Nature. 2016;530:253–4. ID - ref9 ER - TY - JOUR AU - Galvan, A. AU - Ioannidis, J. P. AU - Dragani, T. A. PY - 2010 DA - 2010// TI - Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer JO - Trends Genet VL - 26 UR - https://doi.org/10.1016/j.tig.2009.12.008 DO - 10.1016/j.tig.2009.12.008 ID - Galvan2010 ER - TY - JOUR AU - St Laurent, G. AU - Vyatkin, Y. AU - Kapranov, P. PY - 2014 DA - 2014// TI - Dark matter RNA illuminates the puzzle of genome-wide association studies JO - BMC Med VL - 12 UR - https://doi.org/10.1186/1741-7015-12-97 DO - 10.1186/1741-7015-12-97 ID - St Laurent2014 ER - TY - JOUR AU - Campbell, J. D. AU - Alexandrov, A. AU - Kim, J. AU - Wala, J. AU - Berger, A. H. AU - Pedamallu, C. S. AU - Shukla, S. A. AU - Guo, G. AU - Brooks, A. N. AU - Murray, B. A. AU - Imielinski, M. AU - Hu, X. AU - Ling, S. AU - Akbani, R. AU - Rosenberg, M. AU - Cibulskis, C. AU - Ramachandran, A. AU - Collisson, E. A. AU - Kwiatkowski, D. J. AU - Lawrence, M. S. AU - Weinstein, J. N. AU - Verhaak, R. G. AU - Wu, C. J. AU - Hammerman, P. S. AU - Cherniack, A. D. AU - Getz, G. AU - Cancer Genome Atlas Research, N. AU - Artyomov, M. N. AU - Schreiber, R. AU - Govindan, R. AU - Meyerson, M. PY - 2016 DA - 2016// TI - Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas JO - Nat Genet VL - 48 UR - https://doi.org/10.1038/ng.3564 DO - 10.1038/ng.3564 ID - Campbell2016 ER - TY - JOUR AU - Parker, N. R. AU - Khong, P. AU - Parkinson, J. F. AU - Howell, V. M. AU - Wheeler, H. R. PY - 2015 DA - 2015// TI - Molecular heterogeneity in glioblastoma: potential clinical implications JO - Front Oncol VL - 5 ID - Parker2015 ER - TY - STD TI - GLOBOCAN 2012. http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx. Accessed 11 July 2016. UR - http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx ID - ref14 ER - TY - JOUR AU - Castells, A. AU - Castellvi-Bel, S. AU - Balaguer, F. PY - 2009 DA - 2009// TI - Concepts in familial colorectal cancer: where do we stand and what is the future? JO - Gastroenterology VL - 137 UR - https://doi.org/10.1053/j.gastro.2009.06.015 DO - 10.1053/j.gastro.2009.06.015 ID - Castells2009 ER - TY - JOUR AU - Vasen, H. F. AU - Tomlinson, I. AU - Castells, A. PY - 2015 DA - 2015// TI - Clinical management of hereditary colorectal cancer syndromes JO - Nat Rev Gastroenterol Hepatol VL - 12 UR - https://doi.org/10.1038/nrgastro.2014.229 DO - 10.1038/nrgastro.2014.229 ID - Vasen2015 ER - TY - JOUR PY - 2012 DA - 2012// TI - Comprehensive molecular characterization of human colon and rectal cancer JO - Nature VL - 487 UR - https://doi.org/10.1038/nature11252 DO - 10.1038/nature11252 ID - ref17 ER - TY - JOUR AU - Cutsem, E. AU - Borras, J. M. AU - Castells, A. AU - Ciardiello, F. AU - Ducreux, M. AU - Haq, A. PY - 2013 DA - 2013// TI - Improving outcomes in colorectal cancer: where do we go from here? JO - Eur J Cancer VL - 49 UR - https://doi.org/10.1016/j.ejca.2013.03.026 DO - 10.1016/j.ejca.2013.03.026 ID - Cutsem2013 ER - TY - JOUR AU - Guinney, J. AU - Dienstmann, R. AU - Wang, X. AU - Reynies, A. AU - Schlicker, A. AU - Soneson, C. PY - 2015 DA - 2015// TI - The consensus molecular subtypes of colorectal cancer JO - Nat Med VL - 21 UR - https://doi.org/10.1038/nm.3967 DO - 10.1038/nm.3967 ID - Guinney2015 ER - TY - JOUR AU - Le, D. T. AU - Uram, J. N. AU - Wang, H. AU - Bartlett, B. R. AU - Kemberling, H. AU - Eyring, A. D. PY - 2015 DA - 2015// TI - PD-1 blockade in tumors with mismatch-repair deficiency JO - N Engl J Med VL - 372 UR - https://doi.org/10.1056/NEJMoa1500596 DO - 10.1056/NEJMoa1500596 ID - Le2015 ER - TY - JOUR AU - Hyman, D. M. AU - Puzanov, I. AU - Subbiah, V. AU - Faris, J. E. AU - Chau, I. AU - Blay, J. Y. PY - 2015 DA - 2015// TI - Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations JO - N Engl J Med VL - 373 UR - https://doi.org/10.1056/NEJMoa1502309 DO - 10.1056/NEJMoa1502309 ID - Hyman2015 ER - TY - BOOK PY - 2010 DA - 2010// TI - European guidelines for quality assurance in colorectal cancer screening and diagnosis PB - Publications Office of the European Union CY - Luxembourg ID - ref22 ER - TY - JOUR AU - Quintero, E. AU - Castells, A. AU - Bujanda, L. AU - Cubiella, J. AU - Salas, D. AU - Lanas, A. PY - 2012 DA - 2012// TI - Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening JO - N Engl J Med VL - 366 UR - https://doi.org/10.1056/NEJMoa1108895 DO - 10.1056/NEJMoa1108895 ID - Quintero2012 ER - TY - JOUR AU - Imperiale, T. F. AU - Ransohoff, D. F. AU - Itzkowitz, S. H. AU - Levin, T. R. AU - Lavin, P. AU - Lidgard, G. P. PY - 2014 DA - 2014// TI - Multitarget stool DNA testing for colorectal-cancer screening JO - N Engl J Med VL - 370 UR - https://doi.org/10.1056/NEJMoa1311194 DO - 10.1056/NEJMoa1311194 ID - Imperiale2014 ER - TY - JOUR AU - Moreira, L. AU - Balaguer, F. AU - Lindor, N. AU - Chapelle, A. AU - Hampel, H. AU - Aaltonen, L. A. PY - 2012 DA - 2012// TI - Identification of Lynch syndrome among patients with colorectal cancer JO - JAMA VL - 308 UR - https://doi.org/10.1001/jama.2012.13088 DO - 10.1001/jama.2012.13088 ID - Moreira2012 ER - TY - JOUR AU - Yurgelun, M. B. AU - Allen, B. AU - Kaldate, R. R. AU - Bowles, K. R. AU - Judkins, T. AU - Kaushik, P. PY - 2015 DA - 2015// TI - Identification of a variety of mutations in cancer predisposition genes in patients with suspected Lynch syndrome JO - Gastroenterology VL - 149 UR - https://doi.org/10.1053/j.gastro.2015.05.006 DO - 10.1053/j.gastro.2015.05.006 ID - Yurgelun2015 ER - TY - JOUR AU - Kim, E. H. AU - Andriole, G. L. PY - 2015 DA - 2015// TI - Prostate-specific antigen-based screening: controversy and guidelines JO - BMC Med VL - 13 UR - https://doi.org/10.1186/s12916-015-0296-5 DO - 10.1186/s12916-015-0296-5 ID - Kim2015 ER - TY - BOOK AU - Wilson, J. M. G. AU - Jungner, G. PY - 1968 DA - 1968// TI - Principles and practice of screening for disease PB - World Health Organization CY - Geneva ID - Wilson1968 ER - TY - JOUR AU - Bast, R. C. AU - Feeney, M. AU - Lazarus, H. AU - Nadler, L. M. AU - Colvin, R. B. AU - Knapp, R. C. PY - 1981 DA - 1981// TI - Reactivity of a monoclonal antibody with human ovarian carcinoma JO - J Clin Invest VL - 68 UR - https://doi.org/10.1172/JCI110380 DO - 10.1172/JCI110380 ID - Bast1981 ER - TY - JOUR AU - Buys, S. S. AU - Partridge, E. AU - Black, A. AU - Johnson, C. C. AU - Lamerato, L. AU - Isaacs, C. PY - 2011 DA - 2011// TI - Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial JO - JAMA VL - 305 UR - https://doi.org/10.1001/jama.2011.766 DO - 10.1001/jama.2011.766 ID - Buys2011 ER - TY - JOUR AU - Jacobs, I. J. AU - Menon, U. AU - Ryan, A. AU - Gentry-Maharaj, A. AU - Burnell, M. AU - Kalsi, J. K. PY - 2016 DA - 2016// TI - Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial JO - Lancet VL - 387 UR - https://doi.org/10.1016/S0140-6736(15)01224-6 DO - 10.1016/S0140-6736(15)01224-6 ID - Jacobs2016 ER - TY - JOUR AU - Skates, S. J. PY - 2012 DA - 2012// TI - Ovarian cancer screening: development of the risk of ovarian cancer algorithm (ROCA) and ROCA screening trials JO - Int J Gynecol Cancer VL - 22 UR - https://doi.org/10.1097/IGC.0b013e318256488a DO - 10.1097/IGC.0b013e318256488a ID - Skates2012 ER - TY - JOUR AU - Pinsky, P. F. AU - Zhu, C. AU - Skates, S. J. AU - Black, A. AU - Partridge, E. AU - Buys, S. S. PY - 2013 DA - 2013// TI - Potential effect of the risk of ovarian cancer algorithm (ROCA) on the mortality outcome of the Prostate, Lung, Colorectal and Ovarian (PLCO) trial JO - Int J Cancer VL - 132 UR - https://doi.org/10.1002/ijc.27909 DO - 10.1002/ijc.27909 ID - Pinsky2013 ER - TY - JOUR AU - Taichman, D. B. AU - Backus, J. AU - Baethge, C. PY - 2016 DA - 2016// TI - Sharing clinical trial data--a proposal from the International Committee of Medical Journal Editors JO - N Engl J Med VL - 374 UR - https://doi.org/10.1056/NEJMe1515172 DO - 10.1056/NEJMe1515172 ID - Taichman2016 ER - TY - JOUR AU - Bartlett, J. M. S. AU - McConkey, C. AU - Munro, A. PY - 2015 DA - 2015// TI - Not only, but also: combining TOP2A and CEP17 predicts benefit from anthracyclines in a prospectively planned meta-analysis across five trials JO - J Clin Oncol VL - 33 UR - https://doi.org/10.1200/JCO.2013.54.7869 DO - 10.1200/JCO.2013.54.7869 ID - Bartlett2015 ER - TY - JOUR AU - Pirie, A. AU - Guo, Q. AU - Kraft, P. PY - 2015 DA - 2015// TI - Common germline polymorphisms associated with breast cancer specific survival JO - Breast Cancer Res VL - 17 UR - https://doi.org/10.1186/s13058-015-0570-7 DO - 10.1186/s13058-015-0570-7 ID - Pirie2015 ER - TY - JOUR AU - Abraham, J. E. AU - Guo, Q. AU - Dorling, L. PY - 2014 DA - 2014// TI - Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in breast cancer patients treated with neo-adjuvant and adjuvant paclitaxel JO - Clin Cancer Res VL - 20 UR - https://doi.org/10.1158/1078-0432.CCR-13-3232 DO - 10.1158/1078-0432.CCR-13-3232 ID - Abraham2014 ER - TY - JOUR AU - Schmid, P. AU - Pinder, S. E. AU - Wheatley, D. PY - 2016 DA - 2016// TI - Phase II randomized preoperative window-of-opportunity study of the PI3K inhibitor pictilisib plus anastrozole compared with anastrozole alone in patients with estrogen receptor-positive breast cancer JO - J Clin Oncol VL - 34 UR - https://doi.org/10.1200/JCO.2015.63.9179 DO - 10.1200/JCO.2015.63.9179 ID - Schmid2016 ER - TY - JOUR AU - Loibl, S. AU - Darb-Esfahani, S. AU - Huober, J. PY - 2016 DA - 2016// TI - Integrated analysis of PTEN and p4EBP1 protein expression as predictors for pCR in HER2-positive breast cancer JO - Clin Cancer Res VL - 22 UR - https://doi.org/10.1158/1078-0432.CCR-15-0965 DO - 10.1158/1078-0432.CCR-15-0965 ID - Loibl2016 ER - TY - JOUR AU - Curtis, C. AU - Shah, S. P. AU - Chin, S. F. PY - 2012 DA - 2012// TI - The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups JO - Nature VL - 486 ID - Curtis2012 ER - TY - JOUR AU - Pereira, B. AU - Chin, S. -. F. AU - Rueda, O. M. PY - 2016 DA - 2016// TI - The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes JO - Nat Commun VL - 7 UR - https://doi.org/10.1038/ncomms11479 DO - 10.1038/ncomms11479 ID - Pereira2016 ER - TY - JOUR AU - Dawson, S. J. AU - Tsui, D. W. AU - Murtaza, M. PY - 2013 DA - 2013// TI - Analysis of circulating tumor DNA to monitor metastatic breast cancer JO - N Engl J Med VL - 368 UR - https://doi.org/10.1056/NEJMoa1213261 DO - 10.1056/NEJMoa1213261 ID - Dawson2013 ER - TY - JOUR AU - Garcia-Murillas, I. AU - Schiavon, G. AU - Weigelt, B. PY - 2015 DA - 2015// TI - Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer JO - Sci Transl Med VL - 7 UR - https://doi.org/10.1126/scitranslmed.aab0021 DO - 10.1126/scitranslmed.aab0021 ID - Garcia-Murillas2015 ER - TY - JOUR AU - Islami, F. AU - Torre, L. A. AU - Jemal, A. PY - 2015 DA - 2015// TI - Global trends of lung cancer mortality and smoking prevalence JO - Transl Lung Cancer Res VL - 4 ID - Islami2015 ER - TY - JOUR AU - Pao, W. AU - Girard, N. PY - 2011 DA - 2011// TI - New driver mutations in non-small-cell lung cancer JO - Lancet Oncol VL - 12 UR - https://doi.org/10.1016/S1470-2045(10)70087-5 DO - 10.1016/S1470-2045(10)70087-5 ID - Pao2011 ER - TY - JOUR AU - Janne, P. A. AU - Yang, J. C. AU - Kim, D. W. PY - 2015 DA - 2015// TI - AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer JO - N Engl J Med VL - 372 UR - https://doi.org/10.1056/NEJMoa1411817 DO - 10.1056/NEJMoa1411817 ID - Janne2015 ER - TY - JOUR AU - Oxnard, G. R. AU - Paweletz, C. P. AU - Kuang, Y. PY - 2014 DA - 2014// TI - Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA JO - Clin Cancer Res VL - 20 UR - https://doi.org/10.1158/1078-0432.CCR-13-2482 DO - 10.1158/1078-0432.CCR-13-2482 ID - Oxnard2014 ER - TY - JOUR AU - Maheswaran, S. AU - Sequist, L. V. AU - Nagrath, S. PY - 2008 DA - 2008// TI - Detection of mutations in EGFR in circulating lung-cancer cells JO - N Engl J Med VL - 359 UR - https://doi.org/10.1056/NEJMoa0800668 DO - 10.1056/NEJMoa0800668 ID - Maheswaran2008 ER - TY - JOUR AU - Hellmann, M. D. AU - Friedman, C. F. AU - Wolchok, J. D. PY - 2016 DA - 2016// TI - Combinatorial cancer immunotherapies JO - Adv Immunol VL - 130 UR - https://doi.org/10.1016/bs.ai.2015.12.005 DO - 10.1016/bs.ai.2015.12.005 ID - Hellmann2016 ER - TY - JOUR AU - Shukuya, T. AU - Carbone, D. P. PY - 2016 DA - 2016// TI - Predictive markers for the efficacy of anti-PD-1/PD-L1 antibodies in lung cancer JO - J Thorac Oncol VL - 11 UR - https://doi.org/10.1016/j.jtho.2016.02.015 DO - 10.1016/j.jtho.2016.02.015 ID - Shukuya2016 ER - TY - JOUR AU - Hellmann, M. AU - Ramalingam, S. AU - Reck, M. PY - 2015 DA - 2015// TI - An open label randomized phase III trial of nivolumab or nivolumab plus ipilimumab vs platinum doublet chemotherapy (PT-DC) in patients with chemotherapy naïve stage IV or recurrent non-small cell lung cancer (NSCLC) (Checkmate 227) JO - J Immunother Cancer VL - 3 UR - https://doi.org/10.1186/2051-1426-3-S2-P154 DO - 10.1186/2051-1426-3-S2-P154 ID - Hellmann2015 ER - TY - JOUR AU - Oxnard, G. R. AU - Ramalingam, S. S. AU - Ahn, M. J. PY - 2015 DA - 2015// TI - Preliminary results of TATTON, a multi-arm phase Ib trial of AZD9291 combined with MEDI4736, AZD6094 or selumetinib in EGFR-mutant lung cancer JO - J Clin Oncol VL - 33 ID - Oxnard2015 ER - TY - JOUR AU - Bach, P. B. PY - 2015 DA - 2015// TI - New math on drug cost-effectiveness JO - N Engl J Med VL - 373 UR - https://doi.org/10.1056/NEJMp1512750 DO - 10.1056/NEJMp1512750 ID - Bach2015 ER - TY - JOUR AU - Joshi, M. AU - Ayoola, A. AU - Belani, C. P. PY - 2013 DA - 2013// TI - Small-cell lung cancer: an update on targeted therapies JO - Adv Exp Med Biol VL - 779 UR - https://doi.org/10.1007/978-1-4614-6176-0_18 DO - 10.1007/978-1-4614-6176-0_18 ID - Joshi2013 ER - TY - JOUR AU - Saunders, L. R. AU - Bankovich, A. J. AU - Anderson, W. C. PY - 2015 DA - 2015// TI - A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo JO - Sci Transl Med VL - 7 UR - https://doi.org/10.1126/scitranslmed.aac9459 DO - 10.1126/scitranslmed.aac9459 ID - Saunders2015 ER - TY - JOUR AU - Robinson, D. AU - Allen, E. M. AU - Wu, Y. M. AU - Schultz, N. AU - Lonigro, R. J. PY - 2015 DA - 2015// TI - Integrative clinical genomics of advanced prostate cancer JO - Cell VL - 161 UR - https://doi.org/10.1016/j.cell.2015.05.001 DO - 10.1016/j.cell.2015.05.001 ID - Robinson2015 ER - TY - JOUR AU - Mateo, J. AU - Carriera, S. AU - Sandhu, S. AU - Miranda, S. AU - Mossop, H. PY - 2015 DA - 2015// TI - DNA-repair defects and olaparib in metastatic prostate cancer JO - N Engl J Med VL - 373 UR - https://doi.org/10.1056/NEJMoa1506859 DO - 10.1056/NEJMoa1506859 ID - Mateo2015 ER - TY - JOUR AU - Sandhu, S. K. AU - Schelman, W. R. AU - Wilding, G. AU - Moreno, V. AU - Baird, R. D. PY - 2013 DA - 2013// TI - The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial JO - Lancet Oncol VL - 14 UR - https://doi.org/10.1016/S1470-2045(13)70240-7 DO - 10.1016/S1470-2045(13)70240-7 ID - Sandhu2013 ER - TY - JOUR AU - Gao, D. AU - Vela, I. AU - Sboner, A. AU - Iaquinta, P. J. AU - Karthaus, W. R. PY - 2014 DA - 2014// TI - Organoid cultures derived from patients with advanced prostate cancer JO - Cell VL - 159 UR - https://doi.org/10.1016/j.cell.2014.08.016 DO - 10.1016/j.cell.2014.08.016 ID - Gao2014 ER - TY - JOUR AU - Drost, J. AU - Karthaus, W. R. AU - Gao, D. AU - Driehuis, E. AU - Sawyers, C. L. PY - 2016 DA - 2016// TI - Organoid culture systems for prostate epithelial and cancer tissue JO - Nat Protoc VL - 11 UR - https://doi.org/10.1038/nprot.2016.006 DO - 10.1038/nprot.2016.006 ID - Drost2016 ER -