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Increase in microcephaly cases coincides with increase in ZIKV transmission (with a 6-month delay)
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Data modeling shows that the main period at risk is the first trimester of pregnancy
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Of the microcephaly cases investigated in Brazil, 32 % were linked to ZIKV
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Case study: Miscarriage of a baby with microcephaly was positive for ZIKV (including in its brain), but negative for other known infectious causes of microcephaly
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Laboratory studies
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ZIKV can infect human neural progenitor cells and attenuate their growth in vitro
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Primary human placental macrophages and trophoblasts are permissive to ZIKV infection in vitro
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Animal models
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Mouse model of ZIKV display signs of microcephaly
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Analogy to related viruses
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Rubella virus, another flavivirus, causes microcephaly when infection occurs during pregnancy
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