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Table 2 The risks of all-cause mortality by SF36 vitality score in the EPIC-Norfolk study

From: Fatigue is associated with excess mortality in the general population: results from the EPIC-Norfolk study

Mortality N (%) SF36 vitality score quartile p-valuea
  76–100 65–75 50–64 0–49  
Model A: unadjusted full dataset
HR (95 % CI)
4397/18,101 (24.3 %) 928/4395 (21.1 %) 1103/5047 (21.9 %) 1154/4501 (25.6 %) 1212/4158 (29.1 %) <0.001
1 (reference) 1.04 (0.96–1.14) 1.27 (1.17–1.39) 1.49 (1.36–1.62)
Model B: unadjusted with removal of baseline CVD/cancer
HR (95 % CI)
3637/16,409 (22.2 %) 825/4097 (20.1 %) 945/4657 (20.3 %) 944/4049 (23.3 %) 923/3606 (25.6 %) <0.001
1 (reference) 1.01 (0.92–1.11) 1.20 (1.10–1.32) 1.34 (1.22–1.47)
Model C: confounders
HR (95 % CI)
3388/15,577 (21.8 %) 771/3899 (19.8 %) 886/4442 (19.9 %) 880/3837 (22.9 %) 851/3399 (25.0 %) <0.001
1 (reference) 1.02 (0.93–1.13) 1.21 (1.10–1.34) 1.40 (1.25–1.56)
Model D: confounders + Hb
HR (95 % CI)
3388/15,577 (21.8 %) 771/3899 (19.8 %) 886/4442 (19.9 %) 880/3837 (22.9 %) 851/3399 (25.0 %) <0.001
1(reference) 1.01 (0.91–1.13) 1.24 (1.12–1.39) 1.40 (1.24–1.58)
Model E: confounders + TSH
HR (95 % CI)
3388/15,577 (21.8 %) 771/3899 (19.8 %) 886/4442 (19.9 %) 880/3837 (22.9 %) 851/3399 (25.0 %) <0.001
1 (reference) 0.97 (0.86–1.09) 1.23 (1.09–1.39) 1.26 (1.10–1.45)
Model F: confounders + CRP
HR (95 % CI)
3388/15,577 (21.8 %) 771/3899 (19.8 %) 886/4442 (19.9 %) 880/3837 (22.9 %) 851/3399 (25.0 %) <0.001
1 (reference) 1.06 (0.94–1.19) 1.24 (1.10–1.40) 1.39 (1.21–1.60)
Model G: confounders + Hb, CRP, TSH
HR (95 % CI)
3388/15,577 (21.8 %) 771/3899 (19.8 %) 886/4442 (19.9 %) 880/3837 (22.9 %) 851/3399 (25.0 %) 0.001
1 (reference) 1.00 (0.87–1.15) 1.26 (1.09–1.46) 1.24 (1.05–1.46)
  1. aAcross quartiles
  2. Model A: unadjusted; Model B: unadjusted with removal of baseline CVD/cancer; Model C: Model B + statistically proven confounders – age, gender, body mass index, marital status, smoking, education, alcohol, social class, diet, physical activity, beta blocker, depression, pain, diabetes; Model D: Model C plus Hb adjusted; Model E: Model C plus TSH adjusted; Model F: Model C plus CRP adjusted; Model G: Model C plus Hb, CRP and TSH adjusted
  3. CI confidence interval, CRP C-reactive protein, CVD cardiovascular disease, Hb haemoglobin, HR hazard ratio, TSH thyroid-stimulting hormone