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Table 2 The risks of all-cause mortality by SF36 vitality score in the EPIC-Norfolk study

From: Fatigue is associated with excess mortality in the general population: results from the EPIC-Norfolk study

Mortality

N (%)

SF36 vitality score quartile

p-valuea

 

76–100

65–75

50–64

0–49

 

Model A: unadjusted full dataset

HR (95 % CI)

4397/18,101 (24.3 %)

928/4395 (21.1 %)

1103/5047 (21.9 %)

1154/4501 (25.6 %)

1212/4158 (29.1 %)

<0.001

1 (reference)

1.04 (0.96–1.14)

1.27 (1.17–1.39)

1.49 (1.36–1.62)

Model B: unadjusted with removal of baseline CVD/cancer

HR (95 % CI)

3637/16,409 (22.2 %)

825/4097 (20.1 %)

945/4657 (20.3 %)

944/4049 (23.3 %)

923/3606 (25.6 %)

<0.001

1 (reference)

1.01 (0.92–1.11)

1.20 (1.10–1.32)

1.34 (1.22–1.47)

Model C: confounders

HR (95 % CI)

3388/15,577 (21.8 %)

771/3899 (19.8 %)

886/4442 (19.9 %)

880/3837 (22.9 %)

851/3399 (25.0 %)

<0.001

1 (reference)

1.02 (0.93–1.13)

1.21 (1.10–1.34)

1.40 (1.25–1.56)

Model D: confounders + Hb

HR (95 % CI)

3388/15,577 (21.8 %)

771/3899 (19.8 %)

886/4442 (19.9 %)

880/3837 (22.9 %)

851/3399 (25.0 %)

<0.001

1(reference)

1.01 (0.91–1.13)

1.24 (1.12–1.39)

1.40 (1.24–1.58)

Model E: confounders + TSH

HR (95 % CI)

3388/15,577 (21.8 %)

771/3899 (19.8 %)

886/4442 (19.9 %)

880/3837 (22.9 %)

851/3399 (25.0 %)

<0.001

1 (reference)

0.97 (0.86–1.09)

1.23 (1.09–1.39)

1.26 (1.10–1.45)

Model F: confounders + CRP

HR (95 % CI)

3388/15,577 (21.8 %)

771/3899 (19.8 %)

886/4442 (19.9 %)

880/3837 (22.9 %)

851/3399 (25.0 %)

<0.001

1 (reference)

1.06 (0.94–1.19)

1.24 (1.10–1.40)

1.39 (1.21–1.60)

Model G: confounders + Hb, CRP, TSH

HR (95 % CI)

3388/15,577 (21.8 %)

771/3899 (19.8 %)

886/4442 (19.9 %)

880/3837 (22.9 %)

851/3399 (25.0 %)

0.001

1 (reference)

1.00 (0.87–1.15)

1.26 (1.09–1.46)

1.24 (1.05–1.46)

  1. aAcross quartiles
  2. Model A: unadjusted; Model B: unadjusted with removal of baseline CVD/cancer; Model C: Model B + statistically proven confounders – age, gender, body mass index, marital status, smoking, education, alcohol, social class, diet, physical activity, beta blocker, depression, pain, diabetes; Model D: Model C plus Hb adjusted; Model E: Model C plus TSH adjusted; Model F: Model C plus CRP adjusted; Model G: Model C plus Hb, CRP and TSH adjusted
  3. CI confidence interval, CRP C-reactive protein, CVD cardiovascular disease, Hb haemoglobin, HR hazard ratio, TSH thyroid-stimulting hormone