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Table 4 The risks of cancer related mortality by SF36 vitality score in the EPIC-Norfolk study

From: Fatigue is associated with excess mortality in the general population: results from the EPIC-Norfolk study

Mortality

SF36 vitality score quartiles

p valuea

76–100

65–75

50–64

0–49

 

Model A: unadjusted full dataset

HR (95 % CI)

1 (reference)

0.97 (0.84–1.16)

1.16 (1.01–1.33)

1.10 (0.95–1.27)

0.043

Model B: unadjusted with removal of baseline CVD/cancer

HR (95 % CI)

1 (reference)

0.95 (0.82–1.10)

1.10 (0.95–1.28)

0.98 (0.83–1.15)

0.237

Model C: confounders

HR (95 % CI)

1 (reference)

0.96 (0.83–1.13)

1.14 (0.96–1.34)

1.09 (0.90–1.32)

0.185

Model D: confounders + Hb

HR (95 % CI)

1(reference)

0.94 (0.79–1.11)

1.16 (0.97–1.38)

1.12 (0.91–1.38)

0.086

Model E: confounders + TSH

HR (95 % CI)

1 (reference)

0.91 (0.75–1.10)

1.13 (0.93–1.38)

0.98 (0.77–1.24)

0.132

Model F: confounders + CRP

HR (95 % CI)

1 (reference)

1.06 (0.88–1.27)

1.18 (0.97–1.44)

1.09 (0.87–1.37)

0.385

Model G: confounders + Hb, CRP,TSH

HR (95 % CI)

1 (reference)

1.04 (0.84–1.29)

1.19 (0.95–1.51)

0.86 (0.65–1.15)

0.081

  1. aAcross quartiles
  2. Model A: unadjusted; Model B: unadjusted with removal of baseline CVD/cancer; Model C: Model B + statistically proven confounders – age, gender, body mass index, marital status, smoking, education, alcohol, social class, diet, physical activity, beta blocker, depression, pain, diabetes; Model D: Model C plus Hb adjusted; Model E: Model C plus TSH adjusted; Model F: Model C plus CRP adjusted; Model G: Model C plus Hb, CRP and TSH adjusted
  3. CI confidence interval, CRP C-reactive protein, CVD cardiovascular disease, Hb haemoglobin, HR hazard ratio, TSH thyroid-stimulting hormone