Fig. 1

WISECONDOR plots of sequenced cfDNA showing copy number variations of chromosome 3 in the plasma of five subjects with high-grade serous ovarian carcinomas. From top, Subject 1 diagnosed with a stage 2C, Subject 2 stage 2C, Subject 3 stage 4, Subject 4 stage 3C, Subject 5 stage 3C, and an Ideogram of chromosome 3. Y axis of plots depicts Z-score; red and blue lines are Z-score plotted by windowed and individual bin methods, respectively. Pink and purple bars indicate deviation detected by windowed method or called by windowed method, respectively [12]. Subjects 1, 2, 3, and 5 show whole arm and/or segmental gains of chromosome 3q. Subject 4 shows segmental copy number losses within chromosome 3p and 3q