Table 4 Diagnostic yield for colorectal cancer and significant colonic lesion detection according to the COLONPREDICT classification in the derivation cohort

39.5

29.6

30.9

Colorectal cancer

PPV (%)^d

0.2 (0.0– 1.1)

4.4 (2.8–6.8)

40.7 (36.7–45.9)

NNE (95 % CI)

603 (91–10,000)

22.6 (14.7– 35.7)

2.5 (2.2– 2.7)

OR (95 % CI)

1.0

27.8 (3.7–208)

413 (57.5–2961)

Advanced neoplasia^e

PPV (%)^d

7.1 (5.3– 9.6)

20.8 (17.2– 24.8)

58.1 (53.4– 62.5)

NNE (95 % CI)

14.1 (10.4– 18.9)

4.8 (4.0– 5.8)

1.7 (1.6– 1.9)

OR (95 % CI)

1.0

3.4 (2.3–5.0)

18.0 (12.6–25.8)

Significant colonic lesion^f

PPV (%)^d

8.5 (6.4– 10.0)

24.5 (20.7–28.8)

61.4 (56.9–65.8)

NNE (95 % CI)

11.8 (10.0–15.6)

4.1 (3.5– 4.8)

1.6 (1.5– 1.7)

OR (95 % CI)

1.0

3.5 (2.5–5)

17.2 (12.3–24.3)