Characteristics | Derivation cohort (n = 1572) | Validation cohort (n = 1481) | Significancea |
---|---|---|---|
Age (years) | 68 (20–96) | 64 (19–101) | <0.001 |
Sex (male) | 810 (51.5 %) | 719 (48.5 %) | 0.1 |
Primary healthcare referral (yes) | 360 (22.9 %) | 570 (38.4 %) | <0.001 |
Symptoms | |||
• Change in bowel habit (yes) | 899 (57.2 %) | 778 (52.6 %) | 0.01 |
• Rectal bleeding (yes) | 942 (59.9 %) | 758 (51.2 %) | <0.001 |
Colonoscopy in the last 10 years (yes) | 314 (20.0 %) | 267 (18.0 %) | 0.1 |
Continuous treatment with aspirin (yes) | 224 (14.2 %) | 261 (17.6 %) | 0.01 |
Anorectal examination findings | |||
• Rectal mass (yes) | 38 (2.4 %) | 27 (1.8 %) | 0.2 |
• Benign anorectal lesion (yes) | 646 (41.1 %) | 491 (33.2 %) | <0.001 |
Laboratory results | |||
• Faecal haemoglobin (≥20 μg/g) | 609 (38.7 %) | 491 (33.1 %) | 0.002 |
• Blood haemoglobin (<10 g/dL) | 75 (4.8 %) | 91 (6.1 %) | 0.1 |
• Serum haemoglobin (10–12 g/dL) | 251 (16.0 %) | 239 (16.1 %) | 0.1 |
• CEA (≥3 ng/mL) | 334 (21.2 %) | 341 (23.0 %) | 0.2 |
Bowel cleansing (adequate)b | 1363 (86.7 %) | 1274 (86.0 %) | 0.7 |
Complete colonoscopy (yes) | 1342 (85.4 %) | 1389 (95.0 %) | <0.001 |
Normal colonoscopy (yes) | 855 (38.1 %) | 504 (34.0 %) | 0.01 |
Colorectal cancer (yes) | 214 (13.6 %) | 136 (9.2 %) | <0.001 |
Significant colonic lesion (yes)c | 463 (29.5 %) | 389 (26.3 %) | 0.05 |
• Advanced adenoma (yes) | 251 (16.0 %) | 197 (13.3 %) | 0.04 |
• Polyposis (yes) | 12 (0.8 %) | 11 (0.7 %) | 1 |
• Non adenoma polyp >10 mm (yes) | 6 (0.4 %) | 26 (1.8 %) | <0.001 |
• Colitis (yes) | 36 (2.3 %) | 67 (4.5 %) | 0.001 |