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Table 1 Applications of regenerative medicine therapies in different medical specialties

From: Transforming healthcare through regenerative medicine

Medical Speciality Pathology Cell/Tissue Therapy Clinical Trial Phase Patient numbers Clinical Trial Study
Pubmed Clinical Trial database
Neurology Parkinson’s Fetal porcine cells Transplantation of embryonic dopamine neurons I, II 34 Fink 2001; Freed 2001
Paraplegia, Spinal cord injuries MSCs transplanted directly into injured spinal cord. Bone marrow nucleated cells injected intrathecally and intravenously coupled with MSC infusion by lumbar puncture I, II 80 Park 2012; Jarocha 2015
Multiple Sclerosis IV infusion of MSCs Haemopoietic stem cell transplants I, II 30 Connick 2012
Cardiology Ischaemic cardiomyopathy, heart failure Transendocardial injection of MSC derived from BM or adipose tissue Intracoronary injection of cardiac stem cells IV infusion of MSC I, II 104 Heldman 2014; Hare 2014; Chugh 2012; Perin 2014
Respiratory Idiopathic pulmonary fibrosis IV infusion of placental- Chambers derived MSC I 8 Chambers 2014
Chronic lung disease IV infusion of HLA-matched allogeneic MSCs derived from BM/umbilical cord I,II 62 Weiss 2013
Rheumatology Osteoarthritis Intra-articular injection of autologous or allogeneic MSC I, II, III 104 Orozco 2013; Jo 2014
Osteogenesis Imperfecta Allogeneic bone marrow derived MSC Haemopoietic stem cell transplant plus MSC infusion I 8 Horwitz 2002; Horwitz 2002
Orthopaedics Fracture healing; Joint resurfacing; Osteoporosis MSC combined with/without calcium sulphate Allogenic bone graft containing stem cells G-CSF-mobilised Haemopoietic stem cells with collagen scaffold for non-union fracture healing I,II 96 Kuoroda 2014; Jones 2015; Bajada 2007
Haematology Hematopoietic stem cell transplant (HSCT); Graft versus Host Disease (GvHD) Prochymal (MSC) for severe refractory acute GvHD MSC infused with or following hematopoietic stem cell transplant I, II, III 240 Prasad 2011; Ringden 2006; Perez-Simon 2011
Opthalmology Macular degeneration ESC-derived retinal pigment epithelium I 2 Schwartz 2012
Gastroenterology Liver cirrhosis; Decompensated liver disease MSC injected into peripheral or portal vein Autologous bone marrow mononuclear cells infused IV for liver cirrhosis UC-MSC IV in fusion in decompensated liver disease I,II 45 Kharaziha 2009; terai 2006; Zhang 2012
Crohn’s disease Autologous hematopoietic)stem cell transplantation for refractory Crohn’s I, II, III 98 Oyama 2005
Endocrinology Diabetes (type I & 2) Stem cell educator therapy with cord blood derived stem cells for insulin resistant type II diabetes Hematopoietic stem cell transplantation for new onset type I diabetes I, II 65 Zhao 2013, D’Addio 2014
Nephrology/Urology Kidney transplant rejection MSC based therapy to prevent rejection in living-related kidney transplants I, II 159 Tan 2012
  1. MSC mesenchymal stem cells, BM Bone marrow, ESC Embryonic Stem cells, iPSC induced Pluripotent stem cells, IV intravenous, G-CSF granulocyte-colony stimulating factor, 3D 3-dimensional, UC umbilical cord