Fig. 2

Each node indicates a treatment included in the analysis. The lines represent the direct (head-to-head) comparisons identified in the literature. The surface area of the nodes (represented as circles) represents the number of patients who received the treatment – the larger the size of the circle, the greater the number of patients who received that treatment. For example, there were more patients treated with mycophenolate mofetil or cyclophosphamide (left side of the figure) than tacrolimus or cyclosporine (right side of the figure). Some treatments are noted outside the nodes simply due to longer names that would not fit within the circle size, proportional to the number of patients that received that treatment