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Is there an added value of faecal calprotectin and haemoglobin in the diagnostic work-up for primary care patients suspected of significant colorectal disease? A cross-sectional diagnostic study

  • Sjoerd G. Elias1Email author,
  • Liselotte Kok1,
  • Niek J. de Wit1,
  • Ben J. M Witteman2,
  • Jelle G. Goedhard3,
  • Mariëlle J. L. Romberg-Camps4,
  • Jean W. M. Muris5 and
  • Karel G. M. Moons1
Contributed equally
BMC Medicine201614:141

Received: 11 June 2016

Accepted: 31 August 2016

Published: 26 September 2016

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
11 Jun 2016 Submitted Original manuscript
Author responded Author comments
Reviewed Reviewer Report
Resubmission - Version 2
Submitted Manuscript version 2
Reviewed Reviewer Report
Resubmission - Version 3
Submitted Manuscript version 3
31 Aug 2016 Editorially accepted
26 Sep 2016 Article published 10.1186/s12916-016-0684-5

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht
Department of Gastroenterology, Gelderse Vallei Hospital
Department of Gastroenterology, Atrium Medical Center
Department of Gastroenterology, Orbis Medical Center
The Department of Family Medicine, Care and Public Health Research Institute (Caphri), Maastricht University