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Table 2 Categorized pre-pregnancy maternal BMI and newborn telomere length

From: Maternal pre-pregnancy body mass index and newborn telomere length

  Cord blood (n = 743) Placenta (n = 702)
Percentage change (95 % CI) P value Percentage change (95 % CI) P value
Unadjusted
 <25 kg/m2 a Ref   Ref  
 Overweightb −3.0 (−6.1 to 0.3) 0.07 −4.2 (−7.9 to −0.3) 0.03
 Obesec −5.7 (−9.8 to −1.3) 0.01 −3.7 (−8.8 to 1.6) 0.17
 Overweight + Obese −3.8 (−6.5 to −1.0) 0.008 −4.1 (−7.3 to −0.7) 0.02
Model A
 <25 kg/m2 Ref   Ref  
 Overweightb −2.5 (−5.6 to 0.8) 0.13 −4.2 (−7.8 to −0.3) 0.04
 Obesec −5.2 (−9.3 to −0.9) 0.02 −3.6 (−8.7 to 1.8) 0.19
 Overweight + Obese −3.3 (−6.0 to −0.5) 0.02 −4.0 (−7.3 to −0.6) 0.02
Model B
 <25 kg/m2 Ref   Ref  
 Overweightb −2.5 (−5.6 to 0.8) 0.14 −4.6 (−8.4 to −0.7) 0.02
 Obesec −5.5 (−9.7 to −1.1) 0.01 −4.2 (−9.3 to 1.3) 0.13
 Overweight + Obese −3.4 (−6.2 to −0.5) 0.01 −4.5 (−7.8 to −1.0) 0.01
  1. Estimates are presented as a percentage change in average relative telomere length
  2. Model A, adjustment for paternal and maternal age at birth, maternal education, newborn gender, gestational age, and birth weight. Model B, additionally adjusted for maternal smoking status, parity, newborn ethnicity, pregnancy complications, and cesarean section
  3. an = 488 for cord blood and n = 455 for placenta
  4. bn = 175 for cord blood and n = 170 for placenta
  5. cn = 80 for cord blood and n = 77 for placenta