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Table 4 Second-line drug resistance by study site and treatment history

From: The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance

Study site

Treatment history

Second-line drug resistance amongst MDR

Total MDR with second-line DST done

Pre-XDR drug resistance profiles of MDR isolates

Susceptible

Pre-XDR

Fluoroquinolones

Injectables

OFX

KAN

CAP

KAN/CAP

N

%

n

%

n

%

n

%

n

%

n

%

Burkina Faso

All

 

1

(100)

0

(0)

1

0

(0)

0

(0)

0

(0)

0

(0)

New

–

–

–

–

0

–

–

–

–

–

–

–

–

Retreatment

1

(100)

0

(0)

1

0

(0)

0

(0)

0

(0)

0

(0)

The Gambia

All

 

9

(75)

3

(25)

12

0

(0)

0

(0)

2

(17)

1

(8)

New

0

(0)

0

(0)

0

0

(0)

0

(0)

0

(0)

0

(0)

Retreatment

9

(75)

3

(25)

12

0

(0)

0

(0)

2

(17)

1

(8)

Ghana

All

 

20

(61)

13

(39)

33

3

(9)

2

(6)

7

(21)

1

(3)

New

0

(0)

2

(100)

2

0

(0)

2

(100)

0

(0)

0

(0)

Retreatment

20

(65)

11

(35)

31

3

(10)

0

(0)

7

(23)

1

(3)

Guinea-Bissau

All

 

1

(100)

0

(0)

1

0

(0)

0

(0)

0

(0)

0

(0)

New

1

(100)

0

(0)

1

0

(0)

0

(0)

0

(0)

0

(0)

Retreatment

–

–

–

–

0

–

–

–

–

–

–

–

–

Mali

All

 

30

(79)

8

(21)

38

1

(3)

1

(3)

5

(13)

1

(3)

New

5

(100)

0

(0)

5

0

(0)

0

(0)

0

(0)

0

(0)

Retreatment

25

(76)

8

(24)

33

1

(3)

1

(3)

5

(16)

1

(3)

Nigeria/Ibadan

All

 

13

(76)

4

(23)

17

2

(12)

0

(0)

2

(12)

0

(0)

New

0

(0)

0

(0)

0

0

(0)

0

(0)

0

(0)

0

(0)

Retreatment

13

(76)

4

(23)

17

2

(12)

0

(0)

2

(12)

0

(0)

Nigeria/Lagos

All

 

59

(91)

6

(9)

65

6

(9)

0

(0)

0

(0)

0

(0)

New

8

(100)

0

(0)

8

0

(0)

0

(0)

0

(0)

0

(0)

Retreatment

51

(89)

6

(11)

57

6

(10)

0

(0)

0

(0)

0

(0)

Senegal

All

 

5

(100)

0

(0)

5

0

(0)

0

(0)

0

(0)

0

(0)

New

2

(100)

0

(0)

2

0

(0)

0

(0)

0

(0)

0

(0)

Retreatment

3

(100)

0

(0)

3

0

(0)

0

(0)

0

(0)

0

(0)

Togo

All

 

20

(74)

7

(26)

27

1

(4)

1

(4)

3

(11)

2

(7)

New

2

(40)

3

(60)

5

1

(20)

0

(0)

1

(20)

1

(20)

Retreatment

18

(82)

4

(18)

22

0

(0)

1

(4)

2

(9)

1

(4)

All study sites

All

 

158

(79)

41

(21)

199

12

(6)

4

(2)

19

(9)

6

(3)

New

18

(78)

5

(22)

23

1

(4)

2

(9)

1

(4)

1

(4)

Retreatment

140

(80)

36

(20)

176

11

(6)

2

(1)

18

(10)

5

(3)

  1. No extensively drug-resistant isolates (XDR) were found in the survey. The proportion of pre-XDR within the population of MDR isolates is displayed as well as a detailed description of pre-XDR isolates and their resistance patterns, stratified by mono-resistance to ofloxacin (OFX), kanamycin (KAN) and capreomycin (CAP) and the combination of the latter two (KAN/CAP)