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Fig. 2 | BMC Medicine

Fig. 2

From: Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone

Fig. 2

a, b Hierarchical clustering of mRNA microarray data revealed two main transcriptional profiles that reflect the allocation of tumors according to their vicinity to the SVZ in general (a; top 222 genes differentially expressed between SVZ+ and SVZ– GBMs (p < 0.01)) and to group II (GBMs contacting the SVZ only) and group III (GBMs contacting the cortex only) tumors in particular (b; top 312 genes; p < 0.01). c There was no overlap between location-dependent (SVZ+/–) gene signatures and the molecular subtypes reported by the TCGA working group. d Box plots depicting differential expression of genes considered as stem cell markers, lineage markers, and markers of three developmental pathways (Notch, Wnt, Sonic Hedgehog (SHH)) as identified by mRNA microarray analysis. Note that significant differences (p < 0.05; marked with asterisk) were observed for a subset of genes only (FZD6, PTCH2, NOTCH2, HES4, NEFH) together with a strong trend for DLL3 (p = 0.0654), notably including three genes with involvement of Notch signaling

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