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Fig. 3 | BMC Medicine

Fig. 3

From: Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone

Fig. 3

a, b Box plots illustrating differential expression of candidate genes in the validation cohort as confirmed by qPCR. a Significant overexpression of HES4 in SVZ+ GBMs. b Significant overexpression of HES4 in group II GBMs. Also, there was a strong trend towards overexpression of DLL3 and NTRK2 in group II GBMs and PIR in group III GBMs. c Location-dependent prognostic significance of NTRK2 in SVZ+ GBMs (left panel) as well as NTRK2 (middle panel) and DLL3 (right panel) in group II GBMs. Superior OS was observed in patients with ≥75 % expression of NTRK2 (Q1 cut-off) and <50 % expression of DLL3 (median cut-off), respectively

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