Table 3 Kaplan–Meier estimates of primary and main secondary outcomes by nutritional status

From: Efficacy of artemether-lumefantrine in relation to drug exposure in children with and without severe acute malnutrition: an open comparative intervention study in Mali and Niger

	SAM		Non-SAM
	n/N^a	Kaplan–Meier estimate (95 % CI)	n/N^a	Kaplan–Meier estimate (95 % CI)	P
Day 28 PCR-corrected ACPR^b
mITT	131/131	100 % (NA)	263/266	98.9 % (96.5–99.6)	0.232
PP	118/118	100 % (NA)	241/244	98.9 % (96.2–99.6)	0.227
Day 42 PCR-corrected ACPR
mITT	131/131	100 % (NA)	262/266	98.3 % (95.6–99.4)	0.168
PP	118/118	100 % (NA)	240/244	98.2 % (95.3–99.3)	0.162
Day 28 uncorrected ACPR
mITT	108/131	81.3 % (73.3–87.2)	223/266	83.5 % (78.4–87.5)	0.611
PP	96/118	81.3 % (73.0–87.3)	203/244	83.2 % (77.9–87.3)	0.668
Day 42 uncorrected ACPR
mITT	102/131	76.4 % (67.9–83.0)	196/266	73.0 % (67.2–78.0)	0.552
PP	91/118	77.1 % (68.4–83.7)	176/244	72.1 % (66.0–77.3)	0.377
Day 28 reinfection
mITT	23/131	18.7 % (12.8–26.8)	39/266	15.2 % (11.3–20.1)	0.374
PP	22/118	18.6 % (12.7–26.9)	37/244	15.3 % (11.4–20.5)	0.412
Day 42 reinfection
mITT	29/131	23.6 % (17.0–32.1)	65/266	25.4 % (20.5–31.2)	0.811
PP	27/118	22.9 % (16.3–31.6)	63/244	26.2 % (21.1–32.3)	0.600

P values were calculated with log-rank test
^aN, total number; n, number with event (adequate response or reinfection)
^bPrimary endpoint
SAM severe acute malnutrition, ACPR adequate clinical and parasitological response, mITT modified intent-to-treat population (N = 397), PP per protocol population (N = 362), CI Wald confidence interval, NA not assessable

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