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Table 2 Negative neuropathology findings in late-life depression

From: Vascular depression consensus report – a critical update

Findings

Reference

No association with microvascular disease

[179]

Cerebrovascular pathology (hemorrhages, infarcts, microinfarcts, lacunes) not more severe than in non-depressed aged

[31, 175, 176, 180]

No increased white matter change

[31, 176]

No increased Alzheimer’s disease pathology

[31, 176, 180, 181]

No increased cerebral amyloid angiopathy (but association between plaque and tangle pathology and life time depression preceding Alzheimer’s disease diagnosis)

[182, 183]

No hippocampal sclerosis

[31]