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Table 1 Number of trials published or added between 1 January 2012 and 15 December 2015

From: How do you design randomised trials for smaller populations? A framework

     Expected hypothetical
     false positivesa
Category Disease PMC ct.gov (PMC | ct.gov)
     40 % 10 % 70 %
Larger Asthma 216 110 4 | 2 1 | 1 6 | 3
Populations Breast cancer 632 897 13 | 18 3 | 4 19 | 27
  Colorectal cancer 470 122 9 | 2 2 | 1 14 | 4
  Lung cancer 380 149 8 | 3 2 | 1 11 | 4
Smaller Muscular dystrophy 9 11 0 | 0 0 | 0 0 | 0
Populations Osteosarcoma 8 2 0 | 0 0 | 0 0 | 0
  1. PMC PubMed Central, ct.gov ClinicalTrials.gov
  2. aAssuming 40 %, 10 % and 70 % positive results in each area and a 5 % type I error rate