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Table 1 Number of trials published or added between 1 January 2012 and 15 December 2015

From: How do you design randomised trials for smaller populations? A framework

    

Expected hypothetical

    

false positivesa

Category

Disease

PMC

ct.gov

(PMC | ct.gov)

    

40 %

10 %

70 %

Larger

Asthma

216

110

4 | 2

1 | 1

6 | 3

Populations

Breast cancer

632

897

13 | 18

3 | 4

19 | 27

 

Colorectal cancer

470

122

9 | 2

2 | 1

14 | 4

 

Lung cancer

380

149

8 | 3

2 | 1

11 | 4

Smaller

Muscular dystrophy

9

11

0 | 0

0 | 0

0 | 0

Populations

Osteosarcoma

8

2

0 | 0

0 | 0

0 | 0

  1. PMC PubMed Central, ct.gov ClinicalTrials.gov
  2. aAssuming 40 %, 10 % and 70 % positive results in each area and a 5 % type I error rate
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BMC Medicine

ISSN: 1741-7015

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