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Table 2 Proportion of patients within “renal function” categories according to the different formulas

From: Renal function estimation and Cockcroft–Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart ‘OMics’ in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives

Formula

MDRD4

CKD-EPI

CG-BSA

P value

RF stage

Patients, n (%)

Events, n (%)

Patients, n (%)

Events, n (%)

Patients, n (%)

Events, n (%)

 

Population-based

 Stage 1: ≥ 90

521 (19.7)

9 (1.7)

425 (16.1)

3 (0.7)

429 (16.2)

4 (0.9)

<0.001

 Stage 2: 60–89

1688 (63.8)

26 (1.5)

1701 (64.3)

29 (1.7)

1410 (53.3)

17 (1.2)

<0.001

 Stage 3a: 45–59

353 (13.3)

11 (3.1)

395 (14.9)

12 (3.0)

602 (22.8)

17 (2.8)

<0.001

 Stage 3b/4/5: < 45

83 (3.1)

6 (7.2)

123 (4.7)

8 (6.5)

203 (7.7)

14 (6.9)

<0.001

Cardiovascular risk

 Stage 1: ≥ 90

1223 (5.9)

27 (2.2)

1165 (5.6)

20 (1.7)

1727 (8.3)

28 (1.6)

<0.001

 Stage 2: 60–89

12,992 (62.2)

388 (3.0)

11,956 (57.2)

335 (2.8)

10,284 (49.2)

253 (2.4)

<0.001

 Stage 3a: 45–59

5325 (25.5)

242 (4.5)

5845 (28.0)

261 (4.5)

6277 (30.0)

293 (4.7)

<0.001

 Stage 3b/4/5: < 45

1355 (6.5)

128 (9.4)

1929 (9.2)

169 (8.8)

2607 (12.5)

211 (8.1)

<0.001

Heart failure

 Stage 1: ≥ 90

229 (12.7)

18 (7.8)

165 (9.2)

7 (4.2)

179 (9.9)

4 (2.2)

<0.001

 Stage 2: 60–89

738 (41.0)

77 (10.4)

685 (38.0)

70 (10.2)

533 (29.6)

45 (8.4)

<0.001

 Stage 3a: 45–59

405 (22.5)

71 (17.5)

428 (23.8)

63 (14.7)

443 (24.6)

62 (14.0)

<0.001

 Stage 3b/4/5: < 45

429 (23.8)

117 (27.3)

523 (29.0)

143 (27.3)

646 (35.9)

172 (26.6)

<0.001

Post-myocardial infarction

 Stage 1: ≥ 90

4277 (15.3)

405 (9.5)

4210 (15.1)

351 (8.3)

4315 (15.8)

337 (7.8)

<0.001

 Stage 2: 60–89

14,328 (51.4)

1670 (11.7)

13,400 (48.1)

1515 (11.3)

11,746 (43.1)

1197 (10.2)

<0.001

 Stage 3a: 45–59

6261 (22.5)

1247 (19.9)

6453 (23.1)

1228 (19.0)

6746 (24.8)

1219 (18.1)

<0.001

 Stage 3b: 30–45

2622 (9.4)

793 (30.2)

3174 (11.4)

924 (29.1)

3744 (13.7)

1090 (29.1)

<0.001

 Stage 4/5: < 30

388 (1.5)

162 (41.8)

639 (2.4)

259 (40.5)

682 (2.6)

280 (41.1)

<0.001

  1. RF renal function, CG-BSA Cockcroft-Gault formula adjusted for body surface area, MDRD4 modification of diet in renal disease-4 formula, CKD-EPI Chronic Kidney Disease Epidemiology Collaboration equation
  2. Events refer to cardiovascular mortality