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Table 2 Proportion of patients within “renal function” categories according to the different formulas

From: Renal function estimation and Cockcroft–Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart ‘OMics’ in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives

Formula MDRD4 CKD-EPI CG-BSA P value
RF stage Patients, n (%) Events, n (%) Patients, n (%) Events, n (%) Patients, n (%) Events, n (%)  
Population-based
 Stage 1: ≥ 90 521 (19.7) 9 (1.7) 425 (16.1) 3 (0.7) 429 (16.2) 4 (0.9) <0.001
 Stage 2: 60–89 1688 (63.8) 26 (1.5) 1701 (64.3) 29 (1.7) 1410 (53.3) 17 (1.2) <0.001
 Stage 3a: 45–59 353 (13.3) 11 (3.1) 395 (14.9) 12 (3.0) 602 (22.8) 17 (2.8) <0.001
 Stage 3b/4/5: < 45 83 (3.1) 6 (7.2) 123 (4.7) 8 (6.5) 203 (7.7) 14 (6.9) <0.001
Cardiovascular risk
 Stage 1: ≥ 90 1223 (5.9) 27 (2.2) 1165 (5.6) 20 (1.7) 1727 (8.3) 28 (1.6) <0.001
 Stage 2: 60–89 12,992 (62.2) 388 (3.0) 11,956 (57.2) 335 (2.8) 10,284 (49.2) 253 (2.4) <0.001
 Stage 3a: 45–59 5325 (25.5) 242 (4.5) 5845 (28.0) 261 (4.5) 6277 (30.0) 293 (4.7) <0.001
 Stage 3b/4/5: < 45 1355 (6.5) 128 (9.4) 1929 (9.2) 169 (8.8) 2607 (12.5) 211 (8.1) <0.001
Heart failure
 Stage 1: ≥ 90 229 (12.7) 18 (7.8) 165 (9.2) 7 (4.2) 179 (9.9) 4 (2.2) <0.001
 Stage 2: 60–89 738 (41.0) 77 (10.4) 685 (38.0) 70 (10.2) 533 (29.6) 45 (8.4) <0.001
 Stage 3a: 45–59 405 (22.5) 71 (17.5) 428 (23.8) 63 (14.7) 443 (24.6) 62 (14.0) <0.001
 Stage 3b/4/5: < 45 429 (23.8) 117 (27.3) 523 (29.0) 143 (27.3) 646 (35.9) 172 (26.6) <0.001
Post-myocardial infarction
 Stage 1: ≥ 90 4277 (15.3) 405 (9.5) 4210 (15.1) 351 (8.3) 4315 (15.8) 337 (7.8) <0.001
 Stage 2: 60–89 14,328 (51.4) 1670 (11.7) 13,400 (48.1) 1515 (11.3) 11,746 (43.1) 1197 (10.2) <0.001
 Stage 3a: 45–59 6261 (22.5) 1247 (19.9) 6453 (23.1) 1228 (19.0) 6746 (24.8) 1219 (18.1) <0.001
 Stage 3b: 30–45 2622 (9.4) 793 (30.2) 3174 (11.4) 924 (29.1) 3744 (13.7) 1090 (29.1) <0.001
 Stage 4/5: < 30 388 (1.5) 162 (41.8) 639 (2.4) 259 (40.5) 682 (2.6) 280 (41.1) <0.001
  1. RF renal function, CG-BSA Cockcroft-Gault formula adjusted for body surface area, MDRD4 modification of diet in renal disease-4 formula, CKD-EPI Chronic Kidney Disease Epidemiology Collaboration equation
  2. Events refer to cardiovascular mortality