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Table 3 Cox-regression models for cardiovascular mortality according to the different formulas and cohorts

From: Renal function estimation and Cockcroft–Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart ‘OMics’ in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives

Variables Univariable: HR (95% CI) P value Adjusted: HR (95% CI) P value
Population-based
 MDRD4
  Categorical   0.001   0.046
  Stage 1: ≥ 90 Reference   Reference  
  Stage 2: 60–89 0.818 (0.382–1.751) 0.605 0.799 (0.370–1.726) 0.568
  Stage 3a: 45–59 1.908 (0.790–4.609) 0.151 1.423 (0.563–3.597) 0.456
  Stage 3b/4/5: < 45 4.624 (1.644–13.008) 0.004 3.004 (0.976–9.247) 0.055
 CKD-EPI
  Categorical   <0.001   0.019
  Stage 1: ≥ 90 Reference   Reference  
  Stage 2: 60–89 2.471 (0.752–8.117) 0.136 2.007 (0.607–6.640) 0.254
  Stage 3a: 45–59 4.968 (1.400–17.635) 0.013 3.122 (0.851–11.456) 0.086
  Stage 3b/4/5: < 45 11.207 (2.967–42.335) <0.001 6.426 (1.610–25.652) 0.008
 CG-BSA
  Categorical   <0.001   <0.001
  Stage 1: ≥ 90 Reference   Reference  
  Stage 2: 60–89 1.367 (0.459–4.070) 0.574 1.078 (0.360–3.230) 0.894
  Stage 3a: 45–59 3.658 (1.226–10.915) 0.020 2.393 (0.787–7.275) 0.124
  Stage 3b/4/5: < 45 9.562 (3.131–29.199) <0.001 5.347 (1.665–17.170) 0.005
Cardiovascular risk
 MDRD4
  Categorical   <0.001   <0.001
  Stage 1: ≥ 90 Reference   Reference  
  Stage 2: 60–89 1.008 (0.682–1.489) 0.969 1.096 (0.740–1.624) 0.647
  Stage 3a: 45–59 1.682 (1.130–2.504) 0.010 1.924 (1.285–2.881) 0.001
  Stage 3b/4/5: < 45 4.308 (2.844–6.526) <0.001 5.138 (3.361–7.857) <0.001
 CKD-EPI
  Categorical   <0.001   <0.001
  Stage 1: ≥ 90 Reference   Reference  
  Stage 2: 60–89 1.292 (0.823–2.029) 0.266 1.391 (0.884–2.190) 0.154
  Stage 3a: 45–59 2.263 (1.436–3.566) <0.001 2.543 (1.605–4.029) <0.001
  Stage 3b/4/5: < 45 5.397 (3.393–8.583) <0.001 6.292 (3.923–10.091) <0.001
 CG-BSA
  Categorical   <0.001   <0.001
  Stage 1: ≥ 90 Reference   Reference  
  Stage 2: 60–89 1.347 (0.911–1.990) 0.135 1.504 (1.009–2.241) 0.045
  Stage 3a: 45–59 2.927 (1.986–4.315) <0.001 3.416 (2.290–5.094) <0.001
  Stage 3b/4/5: < 45 6.277 (4.227–9.322) <0.001 7.520 (4.981–11.353) <0.001
Heart failure
 MDRD4
  Categorical   <0.001   <0.001
  Stage 1: ≥ 90 Reference   Reference  
  Stage 2: 60–89 1.076 (0.643–1.800) 0.781 1.016 (0.605–1.706) 0.952
  Stage 3a: 45–59 1.791 (1.066–3.007) 0.028 1.517 (0.896–2.569) 0.121
  Stage 3b/4/5: < 45 3.298 (2.007–5.420) <0.001 2.824 (1.704–4.680) <0.001
 CKD-EPI
  Categorical   <0.001   <0.001
  Stage 1: ≥ 90 Reference   Reference  
  Stage 2: 60–89 2.194 (1.008–4.774) 0.048 2.248 (1.030–4.906) 0.042
  Stage 3a: 45–59 2.997 (1.372–6.549) 0.006 2.871 (1.306–6.310) 0.009
  Stage 3b/4/5: < 45 6.557 (3.070–14.006) <0.001 5.784 (2.692–12.430) <0.001
 CG-BSA
  Categorical   <0.001   <0.001
  Stage 1: ≥ 90 Reference   Reference  
  Stage 2: 60–89 3.243 (1.164–9.031) 0.024 3.457 (1.240–9.642) 0.018
  Stage 3a: 45–59 5.266 (1.915–14.485) 0.001 5.078 (1.838–14.024) 0.002
  Stage 3b/4/5: < 45 12.388 (4.595–33.398) <0.001 11.006 (4.066–29.793) <0.001
Post-myocardial infarction
 MDRD4
  Categorical   <0.001   <0.001
  Stage 1: ≥ 90 Reference   Reference  
  Stage 2: 60–89 1.243 (1.115–1.385) <0.001 1.296 (1.162–1.446) <0.001
  Stage 3a: 45–59 2.253 (2.014–2.521) <0.001 2.251 (2.009–2.523) <0.001
  Stage 3b: 30–45 3.692 (3.276–4.162) <0.001 3.509 (3.104–3.967) <0.001
  Stage 4/5: < 30 5.509 (4.591–6.610) <0.001 5.076 (4.208–6.123) <0.001
 CKD-EPI
  Categorical   <0.001   <0.001
  Stage 1: ≥ 90 Reference   Reference  
  Stage 2: 60–89 1.363 (1.214–1.531) <0.001 1.427 (1.269–1.603) <0.001
  Stage 3a: 45–59 2.430 (2.158–2.736) <0.001 2.442 (2.165–2.754) <0.001
  Stage 3b: 30–45 3.976 (3.516–4.497) <0.001 3.852 (3.396–4.368) <0.001
  Stage 4/5: < 30 6.098 (5.193–7.160) <0.001 5.765 (4.887–6.800) <0.001
 CG-BSA
  Categorical   <0.001   <0.001
  Stage 1: ≥ 90 Reference   Reference  
  Stage 2: 60–89 1.302 (1.154–1.470) <0.001 1.369 (1.213–1.546) <0.001
  Stage 3a: 45–59 2.447 (2.169–2.761) <0.001 2.523 (2,234–2.849) <0.001
  Stage 3b: 30–45 4.230 (3.744–4.780) <0.001 4.239 (3.745–4.799) <0.001
  Stage 4/5: < 30 6.536 (5.578–7.659) <0.001 6.639 (5.649–7.802) <0.001
  1. Adjusted model for sex, smoking status, history of hypertension, diagnosis of diabetes, heart rate, and systolic blood pressure (not adjusted for hemoglobin or left ventricular ejection fraction due to > 75% of missing values in all datasets)
  2. CG-BSA Cockcroft–Gault formula adjusted for body surface area, MDRD4 Modification of Diet in Renal Disease-4 formula, CKD-EPI Chronic Kidney Disease Epidemiology Collaboration equation