Table 4 C-statistics, integrated discrimination improvement, and net reclassification improvement of restricted cubic spline “renal function” formulas for cardiovascular mortality discrimination and reclassification in the studied cohorts
Cohorts | Model comparison (A vs. B) | C-index A% | C-index B% | ΔC-index% | P value | IDI% (95% CI) | P value | NRI% (95% CI) | P value |
|---|---|---|---|---|---|---|---|---|---|
Population | Model vs. MDRD4 | 72.8 | 75.7 | 2.9 (−0.3 to 6.1) | 0.072 | 0.5 (−0.1 to 4.3) | 0.16 | 16.7 (−2.0 to 44.1) | 0.072 |
Model vs. CKD-EPI | 72.8 | 75.2 | 2.4 (−1.6 to 6.4) | 0.23 | 0.6 (0.1 to 4.8) | 0.016 | 23.4 (−0.9 to 44.4) | 0.054 | |
Model vs. CG-BSA | 72.8 | 77.3 | 4.5 (−0.7 to 9.7) | 0.087 | 1.0 (0.2 to 5.7) | 0.020 | 39.1 (4.6 to 51.2) | 0.020 | |
MDRD4 vs. CKD-EPI | 75.7 | 75.2 | 0.5 (−2.4 to 3.4) | 0.74 | 0.2 (0.0 to 0.8) | 0.026 | 23.2 (−10.7 to 36.8) | 0.20 | |
MDRD4 vs. CG-BSA | 75.7 | 77.3 | 1.6 (−2.8 to 6.1) | 0.48 | 0.5 (0.0 to 2.1) | 0.045 | 27.4 (−6.8 to 47.9) | 0.13 | |
CKD-EPI vs. CG-BSA | 75.2 | 77.3 | 2.1 (−0.1 to 4.4) | 0.067 | 0.4 (−0.2 to 1.6) | 0.14 | 31.3 (−13.9 to 48.1) | 0.17 | |
CV risk | Model vs. MDRD4 | 58.9 | 66.2 | 7.3 (5.2 to 9.5) | <0.001 | 0.9 (0.6 to 1.6) | <0.001 | 18.5 (13.0 to 24.3) | <0.001 |
Model vs. CKD-EPI | 58.9 | 67.5 | 8.6 (6.4 to 10.9) | <0.001 | 1.1 (0.7 to 1.7) | <0.001 | 20.3 (15.3 to 25.8) | <0.001 | |
Model vs. CG-BSA | 58.9 | 70.2 | 11.3 (8.9 to 13.7) | <0.001 | 1.5 (1.0 to 2.4) | <0.001 | 27.3 (21.4 to 32.6) | <0.001 | |
MDRD4 vs. CKD-EPI | 66.2 | 67.5 | 1.3 (0.8 to 1.8) | <0.001 | 0.1 (0.1 to 0.2) | 0.006 | 23.0 (16.7 to 29.5) | <0.001 | |
MDRD4 vs. CG-BSA | 66.2 | 70.2 | 4.0 (2.7 to 5.3) | <0.001 | 0.6 (0.3 to 0.9) | <0.001 | 22.8 (16.8 to 29.1) | <0.001 | |
CKD-EPI vs. CG-BSA | 67.5 | 70.2 | 2.7 (1.7 to 3.7) | <0.001 | 0.4 (0.2 to 0.7) | <0.001 | 21.1 (14.6 to 27.6) | <0.001 | |
Heart failure | Model vs. MDRD4 | 70.7 | 75.0 | 4.2 (1.9 to 6.5) | <0.001 | 2.7 (1.2 to 4.8) | <0.001 | 24.6 (15.9 to 34.1) | <0.001 |
Model vs. CKD-EPI | 70.7 | 75.5 | 4.7 (2.3 to 7.1) | <0.001 | 3.0 (1.5 to 5.2) | <0.001 | 25.5 (15.5 to 34.1) | <0.001 | |
Model vs. CG-BSA | 70.7 | 77.0 | 6.3 (3.6 to 8.9) | <0.001 | 4.4 (2.6 to 7.2) | <0.001 | 29.6 (20.1 to 39.9) | <0.001 | |
MDRD4 vs. CKD-EPI | 75.0 | 75.5 | 0.5 (0.2 to 0.8) | 0.003 | 0.3 (0.1 to 0.5) | 0.006 | 12.7 (1.6 to 23.8) | 0.024 | |
MDRD4 vs. CG-BSA | 75.0 | 77.0 | 2.1 (1.1 to 3.0) | <0.001 | 1.7 (0.8 to 2.7) | <0.001 | 24.9 (14.7 to 34.7) | <0.001 | |
CKD-EPI vs. CG-BSA | 75.5 | 77.0 | 1.6 (0.8 to 2.4) | <0.001 | 1.4 (0.6 to 2.3) | <0.001 | 26.5 (14.4 to 34.5) | <0.001 | |
Post-MI | Model vs. MDRD4 | 61.7 | 66.5 | 4.9 (4.2 to 5.6) | <0.001 | 3.4 (2.9 to 3.9) | <0.001 | 21.1 (19.4 to 22.8) | <0.001 |
Model vs. CKD-EPI | 61.7 | 67.3 | 5.6 (4.9 to 6.4) | <0.001 | 3.8 (3.4 to 4.4) | <0.001 | 22.4 (20.6 to 24.0) | <0.001 | |
Model vs. CG-BSA | 61.7 | 68.8 | 7.1 (6.3 to 7.9) | <0.001 | 4.9 (4.3 to 5.6) | <0.001 | 24.9 (23.0 to 26.5) | <0.001 | |
MDRD4 vs. CKD-EPI | 66.5 | 67.3 | 0.8 (0.6 to 0.9) | <0.001 | 0.5 (0.4 to 0.6) | <0.001 | 16.4 (13.6 to 20.0) | <0.001 | |
MDRD4 vs. CG-BSA | 66.6 | 68.8 | 2.3 (1.9 to 2.6) | <0.001 | 1.6 (1.3 to 1.9) | <0.001 | 20.9 (18.9 to 23.1) | <0.001 | |
CKD-EPI vs. CG-BSA | 67.3 | 68.8 | 1.5 (1.3 to 1.8) | <0.001 | 1.1 (0.9 to 1.4) | <0.001 | 16.6 (13.8 to 20.4) | <0.001 |