Table 2 Univariate Cox regression analysis of connective tissue disease-related interstitial lung disease (CTD-ILD) cases demonstrating variables significantly predictive of mortality: CALIPER indices (top white), visually derived high-resolution computed tomography indices (light grey) other indices (dark grey)

CALIPER score

 Total ILD extent

203

1.02

0.002

1.01

1.03

 Total fibrosis extent

203

1.12

<0.0001

1.08

1.16

 Reticular pattern

203

1.12

<0.0001

1.08

1.16

 Honeycombing

203

1.18

0.0004

1.08

1.29

 Emphysema

203

1.08

0.004

1.02

1.13

 Pulmonary vessel volume

203

1.37

<0.0001

1.19

1.57

VISUAL score

 ILD extent

203

1.02

0.001

1.01

1.03

 Fibrosis extent

203

1.03

<0.0001

1.02

1.04

 Reticular pattern

203

1.02

0.002

1.01

1.03

 Honeycombing

203

1.03

<0.0001

1.02

1.05

 Traction bronchiectasis

203

1.16

<0.0001

1.09

1.24

 Pulmonary artery diameter

203

1.09

0.0002

1.04

1.15

 DLco

189

0.96

0.0004

0.94

0.98

 Kco

189

0.97

0.0003

0.96

0.99

 CPI

180

1.04

0.002

1.01

1.06

 Age

203

1.06

<0.0001

1.04

1.09

 Previous or current smoker

203

2.21

0.001

1.40

3.61

 ECHOCARDIOGRAPHY RVSP

100

1.03

<0.0001

1.02

1.05

Continuous Model Score

 ILD-GAP score

179

1.74

<0.0001

1.45

2.08

 Stratified CT score

179

2.00

<0.0001

1.63

2.45

 Stratified CT-GAP

179

1.65

<0.0001

1.41

1.94

MULTIVARIATE MODEL

 Age

1.07

<0.0001

1.04

1.10

 Previous/current smoker

2.87

0.0003

1.63

5.04

 Pulmonary vessel volume

1.57

<0.0001

1.35

1.82

 Kco

0.98

0.003

0.96

0.99