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Table 3 Model-estimated deviationsa between monthly numbers of pneumococcal meningitis (PM) cases in adults above 64 years old, compared to baseline

From: Impact of pneumococcal conjugate vaccines on pneumococcal meningitis cases in France between 2001 and 2014: a time series analysis

Epidemiological

Number of PM cases per month

Period

PCV7 serotype

P valueb

Delta6 serotypec

P value

Non-vaccine serotype

P value

Total

P value

Baselined

3.7

1.3

2.0

6.7

2003–2004

–0.03 (–0.50 to 0.44)

0.89

+0.3 (–0.51 to 1.19)

0.43

+1.2 (0.34 to 2.03)

0.006

–1.2 (–2.60 to 0.18)

0.09

2004–2005

–0.2 (–0.75 to 0.26)

0.35

+0.5 (–0.35 to 1.41)

0.24

+1.8 (0.94 to 2.62)

<0.001

+0.6 (–0.82 to 2.00)

0.41

2005–2006

–0.6 (–1.18 to –0.10)

0.021

+0.5 (–0.30 to 1.40)

0.20

+1.6 (0.73 to 2.44)

<0.001

–0.4 (–1.79 to 1.01)

0.58

2006–2007

–0.1 (–0.68 to 0.40)

0.60

+1.3 (0.49 to 2.19)

0.002

+2.1 (1.23 to 2.93)

<0.001

+1.5 (0.16 to 2.95)

0.03

2007–2008

–0.9 (–1.47 to –0.39)

<0.001

+1.1 (0.28 to 2.00)

0.009

+2.4 (1.50 to 3.23)

<0.001

+0.3 (–1.11 to 1.69)

0.68

2008–2009

–1.5 (–2.06 to –0.93)

<0.001

+3.7 (2.83 to 4.55)

<0.001

+3.3 (2.41 to 4.18)

<0.001

+1.3 (–0.07 to 2.77)

0.06

2009–2010

–2.8 (–3.39 to –2.28)

<0.001

+2.7 (1.81 to 3.56)

<0.001

+3.1 (2.23 to 4.02)

<0.001

+0.3 (–1.14 to 1.71)

0.69

2010–2011

–3.1 (–3.59 to –2.52)

<0.001

+0.7 (–0.18 to 1.54)

0.12

+3.6 (2.74 to 4.45)

<0.001

+0.6 (–0.66 to 6.44)

0.11

2011–2012

–2.2 (–2.78 to –1.73)

<0.001

–0.4 (–1.26 to 0.45)

0.35

+4.5 (3.64 to 5.36)

<0.001

+0.5 (–0.84 to 1.93)

0.43

2012–2013

–2.7 (–3.28 to –2.15)

<0.001

–1.2 (–2.03 to –0.29)

0.009

+3.3 (2.42 to 4.20)

<0.001

+0.5 (–0.92 to 1.94)

0.48

2013–2014

–3.1 (–3.70 to –2.47)

<0.001

–1.1 (–1.96 to –0.25)

0.010

+2.8 (1.98 to 3.73)

<0.001

–2.0 (–3.36 to –0.57)

0.006

  1. a The number of PM cases/month predicted by the model for a fixed population size without vaccination. Estimates were adjusted to flu-like syndrome frequency, for each 12-month period from 1 July to 30 June, followed by their 95% confidence interval
  2. b P values are for the comparison of each period’s value versus baseline
  3. c Delta6 refers to the six serotypes added to PCV7 to obtain PCV13
  4. d Baseline values are the numbers of expected PM cases per month