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Table 3 Statistically significant results of network meta-analysis in randomized controlled trials

From: Comparative safety and effectiveness of serotonin receptor antagonists in patients undergoing chemotherapy: a systematic review and network meta-analysis

Treatment comparison Number of studies NMA estimate OR (95% CI)a MA estimate OR (95% CI)
Arrhythmia – 3 RCTs, 4 (inconsistency not applicableb)
 No statistically significant results
Mortality – 8 RCTs, 7 treatments, 4823 adults
 No statistically significant results
Evaluation of inconsistency using the design-by-treatment interaction model Chi-squared test: 1.06 P-value: 0.79
Degrees of freedom: 3 Heterogeneity: 0.00
QTc prolongation – 4 RCTs, 7 treatments, 3358 children and adults (inconsistency not applicableb)
 Ondansetron + dexamethasone vs dolasetron + dexamethasone 1 0.34 (0.240.47) 0.34 (0.240.47)
Number of patients without nausea – 44 RCTS, 12 treatments plus placebo, 11,664 adults
 Ondansetron + steroid vs ondansetron 8 1.96 (1.592.41) 2.16 (1.453.23)
 Ondansetron + steroid vs granisetron 1 2.00 (1.632.45) 21.00 (3.35131.51)
 Ondansetron + steroid vs dolasetron NA 2.09 (1.472.97) NA
 Ondansetron + steroid vs dolasetron + steroid NA 0.44 (0.200.96) NA
 Ondansetron + steroid vs palonosetron NA 1.60 (1.062.41) NA
 Ondansetron + steroid vs tropisetron + steroid 1 2.40 (1.493.88) 7.20 (2.0325.51)
 Ondansetron + steroid vs placebo NA 337.68 (18.896035.72) NA
 Granisetron + steroid vs ondansetron NA 1.91 (1.552.34) NA
 Granisetron + steroid vs granisetron 6 1.95 (1.622.34) 1.96 (1.542.50)
 Granisetron + steroid vs dolasetron NA 2.04 (1.442.87) NA
 Granisetron + steroid vs dolasetron + steroid NA 0.43 (0.200.93) NA
 Granisetron + steroid vs palonosetron NA 1.55 (1.042.33) NA
 Granisetron + steroid vs tropisetron + steroid 1 2.34 (1.453.77) 7.20 (1.2940.05)
 Granisetron + steroid vs placebo NA 328.52 (18.405864.44) NA
 Ondansetron vs dolasetron + steroid NA 0.22 (0.100.48) NA
 Ondansetron vs palonosetron + steroid NA 0.53 (0.390.73) NA
 Ondansetron vs tropisetron + steroid NA 0.29 (0.130.62) NA
 Ondansetron vs ramosetron + steroid NA 0.35 (0.190.64) NA
 Ondansetron vs placebo NA 172.34 (9.673070.30) NA
 Granisetron vs dolasetron + steroid NA 0.22 (0.100.47) NA
 Granisetron vs palonosetron + steroid NA 0.52 (0.390.70) NA
 Granisetron vs tropisetron + steroid NA 0.28 (0.130.61) NA
 Granisetron vs ramosetron + steroid NA 0.34 (0.190.62) NA
 Granisetron vs placebo 1 168.85 (9.512996.71) 169.00 (9.522999.80)
 Dolasetron vs dolasetron + steroid 1 0.21 (0.100.42) 0.21 (0.100.42)
 Dolasetron vs palonosetron + steroid NA 0.50 (0.330.76) NA
 Dolasetron vs tropisetron + steroid NA 0.27 (0.120.61) NA
 Dolasetron vs ramosetron + steroid NA 0.33 (0.170.63) NA
 Dolasetron vs placebo NA 161.31 (8.952907.94) NA
 Dolasetron + steroid vs palonosetron NA 3.65 (1.687.94) NA
 Dolasetron + steroid vs palonosetron + steroid NA 2.39 (1.065.39) NA
 Dolasetron + steroid vs tropisetron + steroid NA 5.49 (2.2713.27) NA
 Dolasetron + steroid vs ramosetron + steroid NA 3.19 (1.297.85) NA
 Dolasetron + steroid vs placebo NA 771.35 (39.3515,120.97) NA
 Palonosetron vs tropisetron + steroid NA 0.35 (0.150.83) NA
 Palonosetron vs ramosetron + steroid NA 0.43 (0.220.86) NA
 Palonosetron vs placebo NA 211.46 (11.643841.31) NA
 Palonosetron + steroid vs tropisetron + steroid NA 2.30 (1.353.91) NA
 Palonosetron + steroid vs placebo NA 323.08 (17.935821.31) NA
 Tropisetron + steroid vs tropisetron + steroid 2 0.24 (0.130.44) 0.24 (0.130.44)
 Tropisetron + steroid vs ramosetron + steroid NA 0.29 (0.140.60) NA
 Tropisetron + steroid vs placebo NA 140.45 (7.632585.40) NA
 Tropisetron + steroid vs placebo NA 597.18 (30.3711,744.01) NA
 Ramosetron + steroid vs ramosetron + steroid 1 0.49 (0.310.78) 0.48 (0.290.79)
 Ramosetron + steroid vs placebo NA 242.02 (13.104471.01) NA
 Ramosetron + steroid vs placebo NA 490.92 (26.089241.08) NA
Evaluation of inconsistency using the design-by-treatment interaction model Chi-squared test: 15.91 P-value: 0.1955
Degrees of freedom: 12 Heterogeneity: 0.00
Number of patients without vomiting – 63 RCTs, 12 treatments plus placebo, 15,460 adults
 Ondansetron + steroid vs ondansetron 9 2.46 (1.803.37) 2.47 (1.524.03)
 Ondansetron + steroid vs granisetron 1 2.35 (1.703.25) 21.00 (3.35131.51)
 Ondansetron + steroid vs dolasetron NA 2.83 (1.784.51) NA
 Ondansetron + steroid vs tropisetron 1 2.95 (1.764.94) 7.20 (2.0325.51)
 Ondansetron + steroid vs placebo NA 31.56 (11.4287.23) NA
 Granisetron + steroid vs ondansetron NA 2.31 (1.663.21) NA
 Granisetron + steroid vs granisetron 8 2.21 (1.642.96) 2.40 (1.214.75)
 Granisetron + steroid vs dolasetron NA 2.66 (1.664.27) NA
 Granisetron + steroid vs tropisetron 1 2.77 (1.654.66) 34.52 (1.83650.54)
 Granisetron + steroid vs placebo NA 29.64 (10.7481.82) NA
 Ondansetron vs dolasetron + steroid NA 0.46 (0.240.89) NA
 Ondansetron vs palonosetron 2 0.59 (0.390.89) 0.44 (0.270.73)
 Ondansetron vs palonosetron + steroid NA 0.33 (0.180.59) NA
 Ondansetron vs tropisetron + steroid NA 0.32 (0.120.85) NA
 Ondansetron vs ramosetron + steroid NA 0.37 (0.170.83) NA
 Ondansetron vs placebo 3 12.82 (4.8533.94) 11.02 (3.3036.84)
 Granisetron vs dolasetron + steroid NA 0.48 (0.250.94) NA
 Granisetron vs palonosetron 3 0.62 (0.420.92) 0.69 (0.480.98)
 Granisetron vs palonosetron + steroid NA 0.35 (0.200.62) NA
 Granisetron vs tropisetron + steroid NA 0.34 (0.130.90) NA
 Granisetron vs ramosetron + steroid NA 0.39 (0.180.87) NA
 Granisetron vs placebo 1 13.44 (5.0235.96) 78.00 (6.24974.67)
 Dolasetron vs dolasetron + steroid 1 0.40 (0.200.80) 0.21 (0.090.50)
 Dolasetron vs palonosetron 1 0.51 (0.320.83) 0.55 (0.360.85)
 Dolasetron vs palonosetron + steroid NA 0.29 (0.150.57) NA
 Dolasetron vs tropisetron + steroid NA 0.28 (0.100.79) NA
 Dolasetron vs ramosetron + steroid NA 0.32 (0.140.78) NA
 Dolasetron vs placebo NA 11.14 (3.9431.49) NA
 Dolasetron + steroid vs tropisetron NA 2.61 (1.205.69) NA
 Dolasetron + steroid vs placebo NA 27.92 (8.6290.43) NA
 Palonosetron vs tropisetron NA 2.02 (1.133.63) NA
 Palonosetron vs placebo NA 21.65 (7.6061.72) NA
 Palonosetron + steroid vs tropisetron NA 3.62 (1.787.37) NA
 Palonosetron + steroid vs ramosetron NA 2.24 (1.024.91) NA
 Palonosetron + steroid vs placebo NA 38.78 (12.56119.76) NA
 Tropisetron vs tropisetron + steroid 2 0.27 (0.110.64) 0.27 (0.130.57)
 Tropisetron vs ramosetron + steroid NA 0.31 (0.130.77) NA
 Tropisetron vs placebo NA 10.70 (3.6931.01) NA
 Tropisetron + steroid vs placebo NA 39.86 (10.09157.37) NA
 Ramosetron vs placebo 1 17.30 (6.2048.30) 10.45 (2.2149.38)
 Ramosetron + steroid vs placebo NA 34.31 (10.33113.92) NA
Evaluation of inconsistency using the design-by-treatment interaction model Chi-squared test: 22.14 P-value: 0.1387
Degrees of freedom: 16 Heterogeneity: 0.10
Number of patients without CINV – 27 RCTs, 10 treatments, 10,924 adults
 Ondansetron + steroid vs ondansetron 1 2.16 (1.622.87) 1.96 (1.123.42)
 Ondansetron + steroid vs granisetron NA 2.17 (1.732.72) NA
 Ondansetron + steroid vs palonosetron + steroid NA 0.81 (0.670.98) NA
 Ondansetron + steroid vs tropisetron NA 4.18 (1.998.77) NA
 Ondansetron + steroid vs placebo NA 365.96 (20.446553.02) NA
 Granisetron + steroid vs ondansetron NA 2.23 (1.692.93) NA
 Granisetron + steroid vs granisetron 6 2.24 (1.832.74) 2.35 (1.882.94)
 Granisetron + steroid vs palonosetron + steroid NA 0.84 (0.700.99) NA
 Granisetron + steroid vs tropisetron NA 4.31 (2.079.01) NA
 Granisetron + steroid vs placebo NA 378.03 (21.156756.45) NA
 Ondansetron vs palonosetron + steroid NA 0.38 (0.270.52) NA
 Ondansetron vs ramosetron + steroid NA 0.31 (0.160.59) NA
 Ondansetron vs placebo NA 169.61 (9.483035.34) NA
 Granisetron vs palonosetron + steroid NA 0.37 (0.290.49) NA
 Granisetron vs ramosetron + steroid NA 0.31 (0.160.60) NA
 Granisetron vs placebo 1 168.85 (9.512996.64) 169.00 (9.522999.80)
 Palonosetron vs placebo NA 165.47 (6.554182.08) NA
 Palonosetron + steroid vs tropisetron NA 5.16 (2.4310.97) NA
 Palonosetron + steroid vs placebo NA 452.19 (25.188121.41) NA
 Tropisetron vs ramosetron NA 0.35 (0.140.83) NA
 Tropisetron vs ramosetron + steroid NA 0.16 (0.060.42) NA
 Tropisetron vs placebo NA 87.64 (4.531696.76) NA
 Ramosetron vs ramosetron + steroid 1 0.46 (0.290.73) 0.55 (0.340.89)
 Ramosetron vs placebo NA 253.30 (13.554734.53) NA
 Ramosetron + steroid vs placebo NA 546.71 (28.5810,456.90) NA
Evaluation of inconsistency using the design-by-treatment interaction model Chi-squared test: 11.95 P-value: 0.0631
Degrees of freedom: 6 Heterogeneity: 0.00
Number of patients experiencing severe vomiting – 10 RCTs, 5 treatments, 917 adults
 Ondansetron vs granisetron 4 0.65 (0.450.94) 0.63 (0.430.93)
 Ondansetron vs placebo 3 0.16 (0.040.70) 0.16 (0.040.70)
 Ramosetron vs placebo NA 0.18 (0.030.95) NA
Evaluation of inconsistency using the design-by-treatment interaction model Chi-squared test: 0.33 P-value: 0.5628
Degrees of freedom: 1 Heterogeneity: 0.00
  1. CI confidence interval, CINV chemotherapy-induced nausea and vomiting, MA meta-analysis, NA not applicable, NMA network meta-analysis, OR odds ratio, RCT randomized controlled trial
  2. a Meta-analysis was not conducted for treatment comparisons where only one trial was included; in that situation, the direct estimate was obtained from the single trial
  3. b Number of interventions included in NMA is greater than number of RCTs