Variable

IHD

Cardiovascular mortality

Allcause mortality


N
studies

Scale

Exp(b)^{a}
(95% CI)

P value^{b}

N
studies

Scale

Exp(b)^{a}
(95% CI)

P value^{b}

N
studies

Scale

Exp(b)^{a}
(95% CI)

P value^{b}


Degrees of hypothyroidism

SCH

8

Per unit

0.97 (0.77, 1.22)

0.74

12

Per unit

Reference



18

Per unit

Reference



OHypo

1
 
2.25 (0.44, 11.36)

0.30

0
 




1
 
1.36 (0.12, 15.24)

0.80

All

4
 
Reference



5
 
0.86 (0.61, 1.20)

0.35

21
 
0.93 (0.73, 1.17)

0.51

Study population

13

Per unit

1.05 (0.77, 1.43)

0.73

17

Per unit

1.06 (0.75, 1.50)

0.70

40

Per unit

1.32 (1.08, 1.62)

0.009

Mean age

≥80 years

0

Per unit





1

Per unit

0.36 (0.19, 0.69)

0.004

3

Per unit

Reference



65–79 years

8
 
0.91 (0.70, 1.19)

0.45

11
 
0.70 (0.50, 0.98)

0.04

20
 
1.07 (0.72, 1.59)

0.73

<65 years

5
 
Reference



5
 
Reference



17
 
1.27 (0.86, 1.87)

0.22

Location

Europe

7

Per unit

0.44 (0.10, 1.86)

0.23

7

Per unit

0.57 (0.33, 0.99)

0.045

19

Per unit

1.03 (0.62, 1.71)

0.92

North America

4
 
0.43 (0.10, 1.83)

0.22

5
 
0.63 (0.36, 1.10)

0.097

10
 
1.19 (0.71, 2.01)

0.50

Oceania

1
 
0.71 (0.15, 3.32)

0.63

1
 
0.87 (0.40, 1.90)

0.70

1
 
Reference



Asia

1
 
Reference



4
 
Reference



10
 
1.65 (0.96, 2.82)

0.07

Female proportion

13

Per 1%

0.79 (0.35, 1.75)

0.53

17

Per 1%

0.64 (0.25, 1.64)

0.33

40

Per 1%

0.71 (0.39, 1.29)

0.25

Mean followup years

13

Per 1 year

1.02 (0.99, 1.05)

0.17

17

Per 1 year

1.03 (0.99, 1.06)

0.096

40

Per 1 year

0.99 (0.97, 1.02)

0.53


CI confidence interval, IHD ischemic heart disease, OHypo overt hypothyroidism, SCH subclinical hypothyroidism

^{a}Exp (b) is the exponential of the regression coefficient and describes how the outcome variable changes with a unit increase in the explanatory variable

^{b}
P value for Exp (b)