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Table 3 Univariate meta-regression of hypothyroidism on IHD events and mortality

From: What is the association of hypothyroidism with risks of cardiovascular events and mortality? A meta-analysis of 55 cohort studies involving 1,898,314 participants

Variable IHD Cardiovascular mortality All-cause mortality
N studies Scale Exp(b)a (95% CI) P valueb N studies Scale Exp(b)a (95% CI) P valueb N studies Scale Exp(b)a (95% CI) P valueb
Degrees of hypothyroidism
 SCH 8 Per unit 0.97 (0.77, 1.22) 0.74 12 Per unit Reference - 18 Per unit Reference -
 OHypo 1   2.25 (0.44, 11.36) 0.30 0   - - 1   1.36 (0.12, 15.24) 0.80
 All 4   Reference - 5   0.86 (0.61, 1.20) 0.35 21   0.93 (0.73, 1.17) 0.51
Study population 13 Per unit 1.05 (0.77, 1.43) 0.73 17 Per unit 1.06 (0.75, 1.50) 0.70 40 Per unit 1.32 (1.08, 1.62) 0.009
Mean age
 ≥80 years 0 Per unit - - 1 Per unit 0.36 (0.19, 0.69) 0.004 3 Per unit Reference -
 65–79 years 8   0.91 (0.70, 1.19) 0.45 11   0.70 (0.50, 0.98) 0.04 20   1.07 (0.72, 1.59) 0.73
 <65 years 5   Reference - 5   Reference - 17   1.27 (0.86, 1.87) 0.22
Location
 Europe 7 Per unit 0.44 (0.10, 1.86) 0.23 7 Per unit 0.57 (0.33, 0.99) 0.045 19 Per unit 1.03 (0.62, 1.71) 0.92
 North America 4   0.43 (0.10, 1.83) 0.22 5   0.63 (0.36, 1.10) 0.097 10   1.19 (0.71, 2.01) 0.50
 Oceania 1   0.71 (0.15, 3.32) 0.63 1   0.87 (0.40, 1.90) 0.70 1   Reference -
 Asia 1   Reference - 4   Reference - 10   1.65 (0.96, 2.82) 0.07
Female proportion 13 Per 1% 0.79 (0.35, 1.75) 0.53 17 Per 1% 0.64 (0.25, 1.64) 0.33 40 Per 1% 0.71 (0.39, 1.29) 0.25
Mean follow-up years 13 Per 1 year 1.02 (0.99, 1.05) 0.17 17 Per 1 year 1.03 (0.99, 1.06) 0.096 40 Per 1 year 0.99 (0.97, 1.02) 0.53
  1. CI confidence interval, IHD ischemic heart disease, OHypo overt hypothyroidism, SCH subclinical hypothyroidism
  2. aExp (b) is the exponential of the regression coefficient and describes how the outcome variable changes with a unit increase in the explanatory variable
  3. b P value for Exp (b)