Variable | IHD | Cardiovascular mortality | All-cause mortality | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
N studies | Scale | Exp(b)a (95% CI) | P valueb | N studies | Scale | Exp(b)a (95% CI) | P valueb | N studies | Scale | Exp(b)a (95% CI) | P valueb | |
Degrees of hypothyroidism | ||||||||||||
 SCH | 8 | Per unit | 0.97 (0.77, 1.22) | 0.74 | 12 | Per unit | Reference | - | 18 | Per unit | Reference | - |
 OHypo | 1 |  | 2.25 (0.44, 11.36) | 0.30 | 0 |  | - | - | 1 |  | 1.36 (0.12, 15.24) | 0.80 |
 All | 4 |  | Reference | - | 5 |  | 0.86 (0.61, 1.20) | 0.35 | 21 |  | 0.93 (0.73, 1.17) | 0.51 |
Study population | 13 | Per unit | 1.05 (0.77, 1.43) | 0.73 | 17 | Per unit | 1.06 (0.75, 1.50) | 0.70 | 40 | Per unit | 1.32 (1.08, 1.62) | 0.009 |
Mean age | ||||||||||||
 ≥80 years | 0 | Per unit | - | - | 1 | Per unit | 0.36 (0.19, 0.69) | 0.004 | 3 | Per unit | Reference | - |
 65–79 years | 8 |  | 0.91 (0.70, 1.19) | 0.45 | 11 |  | 0.70 (0.50, 0.98) | 0.04 | 20 |  | 1.07 (0.72, 1.59) | 0.73 |
 <65 years | 5 |  | Reference | - | 5 |  | Reference | - | 17 |  | 1.27 (0.86, 1.87) | 0.22 |
Location | ||||||||||||
 Europe | 7 | Per unit | 0.44 (0.10, 1.86) | 0.23 | 7 | Per unit | 0.57 (0.33, 0.99) | 0.045 | 19 | Per unit | 1.03 (0.62, 1.71) | 0.92 |
 North America | 4 |  | 0.43 (0.10, 1.83) | 0.22 | 5 |  | 0.63 (0.36, 1.10) | 0.097 | 10 |  | 1.19 (0.71, 2.01) | 0.50 |
 Oceania | 1 |  | 0.71 (0.15, 3.32) | 0.63 | 1 |  | 0.87 (0.40, 1.90) | 0.70 | 1 |  | Reference | - |
 Asia | 1 |  | Reference | - | 4 |  | Reference | - | 10 |  | 1.65 (0.96, 2.82) | 0.07 |
Female proportion | 13 | Per 1% | 0.79 (0.35, 1.75) | 0.53 | 17 | Per 1% | 0.64 (0.25, 1.64) | 0.33 | 40 | Per 1% | 0.71 (0.39, 1.29) | 0.25 |
Mean follow-up years | 13 | Per 1Â year | 1.02 (0.99, 1.05) | 0.17 | 17 | Per 1Â year | 1.03 (0.99, 1.06) | 0.096 | 40 | Per 1Â year | 0.99 (0.97, 1.02) | 0.53 |