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Table 3 Univariate meta-regression of hypothyroidism on IHD events and mortality

From: What is the association of hypothyroidism with risks of cardiovascular events and mortality? A meta-analysis of 55 cohort studies involving 1,898,314 participants

Variable

IHD

Cardiovascular mortality

All-cause mortality

N

studies

Scale

Exp(b)a

(95% CI)

P valueb

N

studies

Scale

Exp(b)a

(95% CI)

P valueb

N

studies

Scale

Exp(b)a

(95% CI)

P valueb

Degrees of hypothyroidism

 SCH

8

Per unit

0.97 (0.77, 1.22)

0.74

12

Per unit

Reference

-

18

Per unit

Reference

-

 OHypo

1

 

2.25 (0.44, 11.36)

0.30

0

 

-

-

1

 

1.36 (0.12, 15.24)

0.80

 All

4

 

Reference

-

5

 

0.86 (0.61, 1.20)

0.35

21

 

0.93 (0.73, 1.17)

0.51

Study population

13

Per unit

1.05 (0.77, 1.43)

0.73

17

Per unit

1.06 (0.75, 1.50)

0.70

40

Per unit

1.32 (1.08, 1.62)

0.009

Mean age

 ≥80 years

0

Per unit

-

-

1

Per unit

0.36 (0.19, 0.69)

0.004

3

Per unit

Reference

-

 65–79 years

8

 

0.91 (0.70, 1.19)

0.45

11

 

0.70 (0.50, 0.98)

0.04

20

 

1.07 (0.72, 1.59)

0.73

 <65 years

5

 

Reference

-

5

 

Reference

-

17

 

1.27 (0.86, 1.87)

0.22

Location

 Europe

7

Per unit

0.44 (0.10, 1.86)

0.23

7

Per unit

0.57 (0.33, 0.99)

0.045

19

Per unit

1.03 (0.62, 1.71)

0.92

 North America

4

 

0.43 (0.10, 1.83)

0.22

5

 

0.63 (0.36, 1.10)

0.097

10

 

1.19 (0.71, 2.01)

0.50

 Oceania

1

 

0.71 (0.15, 3.32)

0.63

1

 

0.87 (0.40, 1.90)

0.70

1

 

Reference

-

 Asia

1

 

Reference

-

4

 

Reference

-

10

 

1.65 (0.96, 2.82)

0.07

Female proportion

13

Per 1%

0.79 (0.35, 1.75)

0.53

17

Per 1%

0.64 (0.25, 1.64)

0.33

40

Per 1%

0.71 (0.39, 1.29)

0.25

Mean follow-up years

13

Per 1 year

1.02 (0.99, 1.05)

0.17

17

Per 1 year

1.03 (0.99, 1.06)

0.096

40

Per 1 year

0.99 (0.97, 1.02)

0.53

  1. CI confidence interval, IHD ischemic heart disease, OHypo overt hypothyroidism, SCH subclinical hypothyroidism
  2. aExp (b) is the exponential of the regression coefficient and describes how the outcome variable changes with a unit increase in the explanatory variable
  3. b P value for Exp (b)