Table 2 Symptomatic treatment in CADASIL
| Symptom | Therapy | Effects |
|---|---|---|
| Migraine | Acetazolamide [152–154] | As prophylaxis, reduces the frequency of migraine attacks |
| Sodium valproate [155] | Anecdotal cases | |
| Cognitive decline | Acetylcholinesterase inhibitor [121] | Not efficacious on the primary end-point (Vascular Dementia Assessment scale after 18 weeks), but some improvement in relation to frontal-subcortical dysfunction |
| Primary and secondary stroke prevention | Antiplatelet drugs [66, 123] | Unproven and debated benefits |