Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects

Table 2 Symptomatic treatment in CADASIL

Symptom	Therapy	Effects
Migraine	Acetazolamide [152–154]	As prophylaxis, reduces the frequency of migraine attacks
Migraine	Sodium valproate [155]	Anecdotal cases
Cognitive decline	Acetylcholinesterase inhibitor [121]	Not efficacious on the primary end-point (Vascular Dementia Assessment scale after 18 weeks), but some improvement in relation to frontal-subcortical dysfunction
Primary and secondary stroke prevention	Antiplatelet drugs [66, 123]	Unproven and debated benefits

ISSN: 1741-7015