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Table 2 Symptomatic treatment in CADASIL

From: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects

Symptom Therapy Effects
Migraine Acetazolamide [152154] As prophylaxis, reduces the frequency of migraine attacks
Sodium valproate [155] Anecdotal cases
Cognitive decline Acetylcholinesterase inhibitor [121] Not efficacious on the primary end-point (Vascular Dementia Assessment scale after 18 weeks), but some improvement in relation to frontal-subcortical dysfunction
Primary and secondary stroke prevention Antiplatelet drugs [66, 123] Unproven and debated benefits