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Table 4 Risk of moderate and severe asthma exacerbations using a negative control with nitrate exposure

From: Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study

 

Nitrates

Exposed

Exposed

Crude

Adjusted

casesa

controlsa

IRR

IRR

95% CI

P value

Any exposure

 Severe exacerbation

65

408

1.68

1.19

0.86–1.65

0.287

 Moderate exacerbation

329

2896

1.14

1.10

0.97–1.25

0.131

Acute exposure

 Severe exacerbation

5

45

1.16

1.36

0.50–3.69

0.550

 Moderate exacerbation

40

343

1.16

1.14

0.81–1.59

0.600

Chronic exposure

 Severe exacerbation

60

363

1.75

1.18

0.84–1.65

0.463

 Moderate exacerbation

289

2553

1.14

1.10

0.96–1.26

0.172

  1. aExposed cases/controls, exposed within the 60 day risk window
  2. IRR Incidence Rate Ratios
  3. Adjusted for asthma medication use in the 90 days prior to the index date; respiratory tract infection in the 90 days prior to the index date; hospitalization for asthma in the year prior to the index date; type of CVD medicine use in the year prior to the index date; exact age; smoking status; body mass index; social deprivation; Charlson comorbidity index; and primary care asthma review in the year prior to the index date
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BMC Medicine

ISSN: 1741-7015

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