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Table 2 Treatment strategies for lack of response to pancreatic enzyme replacement therapy (PERT)

From: Practical guide to exocrine pancreatic insufficiency – Breaking the myths

Treatment strategies

 

• Increase dosage

 

• Check compliance with the patient

 

• Add acid inhibitor

 

• Consider adding enzymes during and towards end of meal

 

• Consider microspheres, possibly adding a rapid release enzyme preparation

 

• Look for evidence of concurrent gastrointestinal disorder