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Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort

  • Renée T. Fortner1Email author,
  • Danja Sarink1,
  • Helena Schock1,
  • Theron Johnson1,
  • Anne Tjønneland2,
  • Anja Olsen2,
  • Kim Overvad3,
  • Aurélie Affret4, 5,
  • Mathilde His4, 5,
  • Marie-Christine Boutron-Ruault4, 5,
  • Heiner Boeing6,
  • Antonia Trichopoulou7, 8,
  • Androniki Naska7, 8,
  • Philippos Orfanos7, 8,
  • Domenico Palli9,
  • Sabina Sieri10,
  • Amalia Mattiello11,
  • Rosario Tumino12,
  • Fulvio Ricceri13, 14,
  • H. Bas Bueno-de-Mesquita15, 16, 17,
  • Petra H. M. Peeters18, 19,
  • Carla H. Van Gils18,
  • Elisabete Weiderpass20, 21, 22, 23,
  • Eiliv Lund20,
  • J. Ramón Quirós24,
  • Antonio Agudo25,
  • Maria-José Sánchez26, 27,
  • María-Dolores Chirlaque27, 28, 29,
  • Eva Ardanaz27, 30, 31,
  • Miren Dorronsoro32,
  • Tim Key33,
  • Kay-Tee Khaw34,
  • Sabina Rinaldi35,
  • Laure Dossus35,
  • Marc Gunter35,
  • Melissa A. Merritt16,
  • Elio Riboli16 and
  • Rudolf Kaaks1
BMC Medicine201715:26

Received: 6 September 2016

Accepted: 10 January 2017

Published: 8 February 2017

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Open Peer Review reports

Pre-publication versions of this article are available by contacting

Original Submission
6 Sep 2016 Submitted Original manuscript
30 Sep 2016 Reviewed Reviewer Report - Allan Lipton
26 Nov 2016 Reviewed Reviewer Report - Linda Connelly
16 Dec 2016 Reviewed Reviewer Report - Molin Wang
20 Dec 2016 Author responded Author comments - Renée Fortner
Resubmission - Version 2
20 Dec 2016 Submitted Manuscript version 2
21 Dec 2016 Author responded Author comments - Renée Fortner
Resubmission - Version 3
21 Dec 2016 Submitted Manuscript version 3
29 Dec 2016 Reviewed Reviewer Report - Linda Connelly
9 Jan 2017 Reviewed Reviewer Report - Molin Wang
Resubmission - Version 4
Submitted Manuscript version 4
10 Jan 2017 Editorially accepted
8 Feb 2017 Article published 10.1186/s12916-017-0786-8

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting

You can find further information about the peer review system here.

Authors’ Affiliations

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark
Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France
Gustave Roussy, Villejuif, France
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
Hellenic Health Foundation, Athens, Greece
WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece
Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy
Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
Cancer Registry and Histopathology Unit, “Civic - M.p.Arezzo” Hospital, ASP Ragusa, Italy
Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco (TO), Italy
Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy
Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK
Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland
Public Health Directorate, Asturias, Spain
Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L’Hospitalet de Llobregat, Barcelona, Spain
Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain
Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain
Navarra Public Health Institute, Pamplona, Spain
IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain
Nuffield Department of Population Health, University of Oxford, Oxford, UK
Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK
International Agency for Research on Cancer, Lyon, France