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Table 1 Baseline and case characteristics: EPIC cohort breast cancer nested case-control study

From: Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort

  Cases Controls
Full study population, n 2008 2008
Baseline characteristics, median (10 th –90 th percentiles) or n (%)
 Age at blood collection, years 57 (45-64) 57 (45-64)
 Age at menarche, years 13 (11-15) 13 (11-15)
 Premenopausal 462 (23%) 462 (23%)
 Postmenopausal 1546 (77%) 1546 (77%)
  HT use at blood collectiona 755 (49%) 755 (49%)
 Age at menopause, yearsa 50 (43-55) 50 (43-55)
 Completed term pregnancy 1695 (84%) 1733 (86%)
 Age at first term pregnancy,b years 25 (20-31) 24 (20-30)
 BMI, kg/m2 24 (21-31) 24 (20-30)
Case characteristics
 ER+ 1622 (81%)  
 ER– 386 (19%)  
 ER+/PR + c 929 (63%)  
 ER–/PR– 258 (17%)  
 Age at diagnosis, years 61 (50-70)  
 Time between blood donation and diagnosis, years 4.7 (1.2-8.1)  
Osteoprotegerin concentrations, ng/mL, median (10 th –90 th percentiles)
  0.196 (0.138-0.282) 0.197 (0.141-0.289)
  1. aAmong postmenopausal women
  2. bAmong women with completed term pregnancy
  3. cPR status available for 74% of cases (n = 1480); percentages represent percentage of total cases with ER and PR status available