Skip to main content

Table 3 Circulating concentrations of osteoprotegerin and breast cancer risk by menopausal status at blood collection: EPIC cohort breast cancer nested case-control study

From: Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort

 

Tertiles

   

1

2

3

   

Cut points (ng/mL)

<0.18

0.18 - <0.22

≥0.22

p trend a

RRlog2 c

p het d

Hormone receptor positive cases

Premenopausal

  ER+/PR+

   Cases/controls

168/152

61/77

24/24

   

   RR (95% CI)

Ref.

0.67 (0.43-1.04)

0.89 (0.42-1.87)

0.07

0.58 (0.32-1.05)

0.36

  ER+

      

   Cases/controls

236/200

79/118

37/34

   

   RR (95% CI)

Ref.

0.55 (0.38-0.81)

0.85 (0.47-1.55)

0.01b

0.53 (0.31-0.88) b

0.05 b

Postmenopausal

      

  ER+/PR+

   Cases/controls

174/160

236/231

266/285

   

   RR (95% CI)

Ref.

0.92 (0.68-1.24)

0.85 (0.61-1.17)

0.73

0.94 (0.66-1.33)

 

  ER+

   Cases/controls

323/310

440/426

507/534

   

   RR (95% CI)

Ref.

0.98 (0.78-1.22)

0.91 (0.72-1.15)

0.79

0.97 (0.75-1.25)

 

Hormone receptor negative cases

    

Premenopausal

  ER–/PR–

   Cases/controls

35/44

18/17

14/6

   

   RR (95% CI)

Ref.

1.60 (0.57-4.44)

3.77 (0.86-16.4)

0.25

2.01 (0.60-6.70)

0.87

  ER–

      

   Cases/controls

59/70

30/30

21/10

   

   RR (95% CI)

Ref.

1.42 (0.67-2.99)

3.21 (1.17-8.85)

0.26

1.63 (0.70-3.84)

0.97

Postmenopausal

  ER–/PR–

   Cases/controls

47/52

60/79

84/60

   

   RR (95% CI)

Ref.

1.02 (0.55-1.89)

2.03 (1.03-3.98)

0.14

1.76 (0.82-3.77)

 

  ER–

   Cases/controls

80/90

87/95

109/91

0.12

1.62 (0.88-2.96)

 

   RR (95% CI)

Ref.

1.14 (0.68-1.90)

1.60 (0.95-2.69)

   
  1. Conditional logistic regression models adjusted for ages at menarche (≤12, 13, 14, ≥15, missing), menopause (<44, 44-47, 48-50, 51-52, 53-54, ≥55, missing), first full-term pregnancy (no FTP, <25, 25-30, ≥30, missing), number of full-term pregnancies (0, 1, 2, ≥3, missing), and BMI (kg/m2, continuous)
  2. a p trend based on log2-transformed continuous variable
  3. bEvidence of non-linear association, p = 0.03; see Additional file 1: Figure S1
  4. cRR for a one-unit change in log2-transformed OPG
  5. d p heterogeneity comparing women premenopausal to postmenopausal at blood collection based on RRlog2; among postmenopausal women, results did not differ by HT use at blood collection (p ≥ 0.43)