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Table 3 Circulating concentrations of osteoprotegerin and breast cancer risk by menopausal status at blood collection: EPIC cohort breast cancer nested case-control study

From: Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort

  Tertiles    
1 2 3    
Cut points (ng/mL) <0.18 0.18 - <0.22 ≥0.22 p trend a RRlog2 c p het d
Hormone receptor positive cases
Premenopausal
  ER+/PR+
   Cases/controls 168/152 61/77 24/24    
   RR (95% CI) Ref. 0.67 (0.43-1.04) 0.89 (0.42-1.87) 0.07 0.58 (0.32-1.05) 0.36
  ER+       
   Cases/controls 236/200 79/118 37/34    
   RR (95% CI) Ref. 0.55 (0.38-0.81) 0.85 (0.47-1.55) 0.01b 0.53 (0.31-0.88) b 0.05 b
Postmenopausal       
  ER+/PR+
   Cases/controls 174/160 236/231 266/285    
   RR (95% CI) Ref. 0.92 (0.68-1.24) 0.85 (0.61-1.17) 0.73 0.94 (0.66-1.33)  
  ER+
   Cases/controls 323/310 440/426 507/534    
   RR (95% CI) Ref. 0.98 (0.78-1.22) 0.91 (0.72-1.15) 0.79 0.97 (0.75-1.25)  
Hormone receptor negative cases     
Premenopausal
  ER–/PR–
   Cases/controls 35/44 18/17 14/6    
   RR (95% CI) Ref. 1.60 (0.57-4.44) 3.77 (0.86-16.4) 0.25 2.01 (0.60-6.70) 0.87
  ER–       
   Cases/controls 59/70 30/30 21/10    
   RR (95% CI) Ref. 1.42 (0.67-2.99) 3.21 (1.17-8.85) 0.26 1.63 (0.70-3.84) 0.97
Postmenopausal
  ER–/PR–
   Cases/controls 47/52 60/79 84/60    
   RR (95% CI) Ref. 1.02 (0.55-1.89) 2.03 (1.03-3.98) 0.14 1.76 (0.82-3.77)  
  ER–
   Cases/controls 80/90 87/95 109/91 0.12 1.62 (0.88-2.96)  
   RR (95% CI) Ref. 1.14 (0.68-1.90) 1.60 (0.95-2.69)    
  1. Conditional logistic regression models adjusted for ages at menarche (≤12, 13, 14, ≥15, missing), menopause (<44, 44-47, 48-50, 51-52, 53-54, ≥55, missing), first full-term pregnancy (no FTP, <25, 25-30, ≥30, missing), number of full-term pregnancies (0, 1, 2, ≥3, missing), and BMI (kg/m2, continuous)
  2. a p trend based on log2-transformed continuous variable
  3. bEvidence of non-linear association, p = 0.03; see Additional file 1: Figure S1
  4. cRR for a one-unit change in log2-transformed OPG
  5. d p heterogeneity comparing women premenopausal to postmenopausal at blood collection based on RRlog2; among postmenopausal women, results did not differ by HT use at blood collection (p ≥ 0.43)