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Table 3 Cord blood cardiometabolic markers between randomised treatment groups

From: The effect of an antenatal lifestyle intervention in overweight and obese women on circulating cardiometabolic and inflammatory biomarkers: secondary analyses from the LIMIT randomised trial

Outcome Lifestyle advice group Standard care group Estimated difference (95% CI) (unadjusted) P value (unadjusted) Estimated difference (95% CI) (adjusted)a P value (adjusted)
Cholesterol (mmol/L) 1.79 (0.71) 1.80 (0.73) 0.01 (–0.07, 0.09) 0.858 0.01 (–0.07, 0.09) 0.853
CRPb,c mg/L 0.30 (0.30, 0.30) 0.30 (0.27, 0.30) 1.16 (0.74, 1.82) 0.513 1.09 (0.69, 1.72) 0.701
Glucosec (mmol/L) 3.53 (1.38) 3.53 (1.46) 0.00 (–0.16, 0.17) 0.968 –0.00 (–0.16, 0.16) 0.984
HDL (mmol/L) 0.63 (0.25) 0.63 (0.25) –0.01 (–0.03, 0.02) 0.680 –0.01 (–0.04, 0.02) 0.548
Insulinb,c (μIU/mL) 10.04 (6.22, 14.93) 9.41 (5.97, 14.75) 1.06 (0.98, 1.14) 0.142 1.07 (0.99, 1.15) 0.085
NEFAb,c (mmol/L) 0.19 (0.13, 0.27) 0.19 (0.13, 0.28) 0.97 (0.91, 1.04) 0.424 0.96 (0.90, 1.03) 0.276
Triglyceridesb,c (mmol/L) 0.39 (0.27, 0.56) 0.40 (0.26, 0.57) 1.01 (0.94, 1.09) 0.767 0.98 (0.91, 1.05) 0.565
LDL (mmol/L) 1.06 (0.54) 1.07 (0.58) 0.01 (–0.05, 0.08) 0.689 0.02 (–0.05, 0.08) 0.639
Adiponectin (μg/mL) 22.35 (16.93, 28.61) 22.28 (16.77, 28.74) 1.00 (0.95, 1.05) 0.945 1.00 (0.94, 1.05) 0.897
Leptin (ng/mL) 13.06 (7.98, 20.95) 13.13 (7.90, 21.97) 0.98 (0.90, 1.07) 0.607 0.98 (0.90, 1.07) 0.701
  1. aAdjustment for centre, parity, BMI category (stratification variables), Socio-Economic Indexes for Areas Index of Relative Socio-Economic Disadvantage quintile, smoking status, and maternal age at consent
  2. bOutcomes were log-transformed; descriptives for these outcomes are median and interquartile range, and estimates are ratios of geometric means (approximately ratios of medians)
  3. All other outcomes are mean and standard deviation, and estimates are differences of means
  4. cOutcomes were modelled using Tobit regression due to presence of values above and/or below detection limits
  5. CRP C-reactive protein, HDL high-density lipoprotein cholesterol, NEFA non-esterified fatty acids, LDL low-density lipoprotein cholesterol