Table 2 Mean (±standard error) estimates derived from mixed model repeated measures (MMRM, unadjusted estimates) comparing differences between the dietary support (DS) and social support (SS) groups in terms of changes from baseline to primary endpoint of 12 weeks
Characteristic | DS | SS | Between-group differences in change from baseline to 12 weeks | ||||||
|---|---|---|---|---|---|---|---|---|---|
Baseline | 12 weeks | Baseline | 12 weeks | ||||||
M (SE) | M (SE) | M (SE) | M (SE) | M (SE) | 95% CI [LCI, UCI] | t a | df | p | |
Symptoms | |||||||||
MADRS (0-60) | 26.1 (1.0) | 14.8 (1.1) | 24.7 (1.0) | 20.5 (1.2) | 7.1 (1.6) | 3.9, 10.4 | 4.38 | 60.7 | <.001 |
HADS – (D) (0-21) | 10.0 (0.6) | 5.3 (0.7) | 9.2 (0.6) | 6.8 (0.7) | 2.3 (1.1) | 0.2, 4.4 | 2.20 | 55.1 | .032 |
HADS – (A) (0-21) | 12.1 (0.6) | 8.4 (0.6) | 11.2 (0.6) | 9.5 (0.7) | 2.0 (0.9) | 0.2, 3.9 | 2.19 | 59.0 | .033 |
Mood | |||||||||
POMS (-32–200) | 54.5 (6.0) | 30.3 (6.5) | 40.9 (5.8) | 32.1 (6.7) | 15.4 (9.9) | -4.6, 35.3 | 1.56 | 43.5 | .127 |
Self-efficacy | |||||||||
GSE (10-40) | 24.6 (1.0) | 28.1 (1.0) | 25.7 (1.0) | 26.7 (1.1) | -2.4 (1.6) | -5.7, 0.9 | -1.44 | 59.0 | .156 |
Wellbeing | |||||||||
WHO-5 (0-25) | 6.9 (0.8) | 12.3 (0.9) | 6.7 (0.8) | 10.3 (1.0) | -1.8 (1.7) | -5.2, 1.6 | -1.04 | 62.0 | .304 |
Anthropometry | |||||||||
BMI | 30.0 (1.4) | 29.9 (1.4) | 29.0 (1.4) | 29.1 (1.4) | 0.15 (0.27) | -0.4, 0.7 | 0.56 | 47.0 | .579 |
Physical activity (IPAQ scores) | 2307.7 (664.8) | 2251.3 (645.9) | 2509.4 (636.3) | 2892.2 (636.3) | 439.3 (1097.6) | -1757.2, 2635 | 0.40 | 58.9 | .690 |
Diet | |||||||||
ModiMedDiet (0-120) | 36.2 (2.5) | 55.1 (2.8) | 47.3 (2.6) | 45.4 (2.9) | -20.7 (4.3) | -20.7, -12.1 | -4.78 | 55.62 | <.001 |
Biomarkers | |||||||||
Glucose (mmol/L) | 4.5 (0.5) | 4.7 (5.5) | 5.4 (0.5) | 5.5 (0.6) | -0.1 (4.3) | -0.9, 0.8 | -0.10 | 48.5 | .919 |
Cholesterol (mmol/L) | 4.9 (0.2) | 4.8 (0.2) | 5.5 (0.2) | 5.2 (0.2) | -0.2 (0.2) | -0.5, 0.2 | -1.08 | 47.7 | .287 |
Triglycerides (mmol/L) | 1.3 (0.2) | 1.2 (0.2) | 1.4 (0.2) | 1.5 (0.2) | 0.2 (0.2) | -0.3, 0.7 | 0.88 | 53.4 | .386 |
HDL cholesterol (mmol/L) | -1.5 (0.1) | 1.5 (0.1) | 1.4 (0.1) | 1.3 (0.1) | -0.1 (0.1) | -0.2, 0.1 | -1.11 | 47.7 | .272 |
LDL cholesterol (mmol/L) | 2.9 (0.2) | 2.8 (0.1) | 3.4 (0.2) | 3.2 (0.2) | -0.1 (0.2) | -0.4, 0.3 | -0.48 | 47.1 | .636 |
Total saturates (% FA) | 35.7 (0.5) | 36.6 (0.5) | 35.6 (0.5) | 38.1 (0.6) | 1.6 (1.0) | -0.5, 3.6 | 1.54 | 62.1 | .128 |
Total monounsaturates (% FA) | 23.2 (0.4) | 22.2 (0.5) | 22.8 (0.4) | 23.2 (0.6) | 1.4 (0.8) | -0.3, 3.1 | 1.69 | 55.4 | .096 |
Total polyunsaturates (% FA) | 41.1 (0.7) | 41.3 (0.8) | 41.6 (0.7) | 38.6 (0.9) | -3.1 (1.3) | -5.7, 0.5 | -2.41 | 54.9 | .019 |
n6 (% PUFA) | 14.6 (0.4) | 14.5 (0.4) | 14.3 (0.4) | 12.8 (0.5) | -1.4 (0.8) | -3.0, 0.3 | -1.69 | 62.1 | .096 |
n3 (% PUFA) | 6.9 (0.3) | 6.8 (0.3) | 6.5 (0.3) | 7.2 (0.4) | 0.9 (0.6) | -0.3, 2.1 | 1.57 | 57.8 | .123 |