Fig. 3
From: Translational models for vascular cognitive impairment: a review including larger species
Structural MRI of canine brains. Coronal MRI scans (1.5 Tesla) of 4-, 9-, and 15-year-old dogs, taken from locations at the level of thalamus (upper row) and hippocampus (lower row). Older animals show marked increase in ventricular volume (black arrows) and cortical atrophy, with deep gyri and widened sulci (white arrows). Three-dimensional images across the whole brain were acquired using a spoiled gradient recall (SPGR) sequence to obtain detailed anatomic images. Modified from [129] with permission