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Table 4 Relationship of mitochondrial number to mitochondrial function and dynamics genes after biliopancreatic diversion (BPD), laparoscopic greater curvature plication (LGCP) and laparoscopic adjustable gastric banding (LAGB) bariatric procedures

From: Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery

  Mitochondrial number vs. BPD (n = 12) LGCP (n = 15) LAGB (n = 12)
Function PGC1α 0.794** –0.688** –0.175
POLG 0.867** –0.407 0.035
TFAM 0.479 –0.560* –0.154
mtND6 0.758* –0.613* –0.153
SDHA 0.855** –0.600* –0.056
COX4I1 0.939** –0.442 0.147
mtATP6 0.782** –0.547* 0.056
UCP2 0.818** –0.389 0.063
SOD1 0.842** –0.604* 0.098
SOD2 0.696* –0.576* –0.017
Dynamics MFN2 0.983** –0.493 0.939*
OPA1 0.808* –0.202 0.963*
DRP1 0.302 –0.426 0.669
FIS1 0.871* –0.337 0.209
  1. Table shows Pearson’s correlation coefficient between mitochondrial number and genes involved in mitochondrial biogenesis (PGC1α, POLG, TFAM), oxidative phosphorylation (mtND6, SDHA, COX4I1, mtATP6), uncoupling (UCP2), antioxidant (SOD1, SOD2), fusion (MFN2, OPA1) and fission (DRP1, FIS1) processes. Correlations were calculated using change variables (pre- to 6-months post-surgery percentage change). *P < 0.05, **P < 0.01
  2. PGC1α Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, POLG mitochondrial DNA polymerase gamma catalytic subunit, TFAM mitochondrial transcription factor A, mtND6 mitochondrially encoded NADH dehydrogenase 6, SDHA Succinate dehydrogenase complex subunit A, COX4I1 Cytochrome c oxidase subunit 4 isoform 1 (complex IV), mtATP6 mitochondria-DNA-encoded ATP synthase subunit 6 (complex V), UCP2 uncoupling protein 2, SOD1 superoxide dismutase 1