Skip to main content

Table 4 Relationship of mitochondrial number to mitochondrial function and dynamics genes after biliopancreatic diversion (BPD), laparoscopic greater curvature plication (LGCP) and laparoscopic adjustable gastric banding (LAGB) bariatric procedures

From: Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery

 

Mitochondrial number vs.

BPD (n = 12)

LGCP (n = 15)

LAGB (n = 12)

Function

PGC1α

0.794**

–0.688**

–0.175

POLG

0.867**

–0.407

0.035

TFAM

0.479

–0.560*

–0.154

mtND6

0.758*

–0.613*

–0.153

SDHA

0.855**

–0.600*

–0.056

COX4I1

0.939**

–0.442

0.147

mtATP6

0.782**

–0.547*

0.056

UCP2

0.818**

–0.389

0.063

SOD1

0.842**

–0.604*

0.098

SOD2

0.696*

–0.576*

–0.017

Dynamics

MFN2

0.983**

–0.493

0.939*

OPA1

0.808*

–0.202

0.963*

DRP1

0.302

–0.426

0.669

FIS1

0.871*

–0.337

0.209

  1. Table shows Pearson’s correlation coefficient between mitochondrial number and genes involved in mitochondrial biogenesis (PGC1α, POLG, TFAM), oxidative phosphorylation (mtND6, SDHA, COX4I1, mtATP6), uncoupling (UCP2), antioxidant (SOD1, SOD2), fusion (MFN2, OPA1) and fission (DRP1, FIS1) processes. Correlations were calculated using change variables (pre- to 6-months post-surgery percentage change). *P < 0.05, **P < 0.01
  2. PGC1α Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, POLG mitochondrial DNA polymerase gamma catalytic subunit, TFAM mitochondrial transcription factor A, mtND6 mitochondrially encoded NADH dehydrogenase 6, SDHA Succinate dehydrogenase complex subunit A, COX4I1 Cytochrome c oxidase subunit 4 isoform 1 (complex IV), mtATP6 mitochondria-DNA-encoded ATP synthase subunit 6 (complex V), UCP2 uncoupling protein 2, SOD1 superoxide dismutase 1
Back to article page

BMC Medicine

ISSN: 1741-7015

Contact us