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Fig. 4 | BMC Medicine

Fig. 4

From: Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome

Fig. 4

Influence of methylome at birth on adiposity outcomes in early childhood: Associations of child weight (a) and body mass index (b) at different time points with DNA methylation at birth. Colour in heatmap represents regression coefficients for associations between child anthropometric outcome and methylation. Each row represents a CpG and each column represents a time point. With increasing magnitudes, colour changes from white to red (for negative coefficients) or from white to grey (for positive coefficients). Asterisks within each square represent P values for associations between child anthropometric outcome and methylation (P < 5 × 10–8 is represented with eight asterisks, 5 × 10–8 ≤ P < 5 × 10–7 is represented with seven asterisks, 5 × 10–3 ≤ P < 5 × 10–2 is represented with two asterisks, P ≥ 5 × 10–2 is represented with a blank square). Analysis was done by linear regression of log-transformed child anthropometric outcome at each time point against methylation at each CpG site, adjusted for child sex, gestational age, ethnicity, cellular proportions and interactions between ethnicity and cellular proportions. Regression coefficients and P values are reported as percentage change in child anthropometric outcome for 10% increase in percent methylation

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