Table 2 Effects of oxytocin versus placebo on cardiac parameters and trauma-related psychopathological symptoms at baseline and in response to trauma-script challenge
| Â | Placebo | Oxytocin | Repeated effects comparison (LMM) | Effect size | |||
|---|---|---|---|---|---|---|---|
baseline | Trauma script | baseline | Trauma script | Â | Â | Â | |
mean (SD) | mean (SD) | mean (SD) | mean (SD) | F (DF) | p-value | Cohen’s d (95% CI) | |
HR (bpm) | 75.9 (9.6) | 82.1 (11.4) | 77.9 (8.9) | 87.2 (15.0) | 3.0 (34) | 0.059t | 0.291 (−0.00–0.50) |
HR max (bpm) |  | 88.1 (12.6) |  | 93.8 (15.2) | 12.8 (34) | 0.020* | 0.605 (0.34–0.87) |
HRV (ms) | 3.15 (.65) | 2.91 (.79) | 3.05 (.79) | 2.79 (.85) | 0.26 (34) | 0.67 | 0.088 (−0.15–0.33) |
PEP (ms) | 76.0 (12.2) | 74.2 (12.9) | 74.4 (13.6) | 70.0 (17.7) | 8.8 (33) | 0.007** | 0.515 (0.26–0.77) |
RESP (bpm) | 15.6 (3.0) | 17.1 (3.8) | 15.1 (3.1) | 16.7 (4.2) | 0.01 (34) | 0.95 | 0.001 (−0.39–0.41) |
RSDI-total |  | 2.87 (1.1) |  | 2.44 (.90) | 7.1 (34) | 0.012* | 0.459 (0.13–0.79) |
RSDI-Re-experiencing |  | 3.74 (1.3) |  | 3.30 (1.2) | 2.2 (34) | 0.15 | 0.342 (−0.11–0.70) |
RSDI-Avoidance |  | 2.52 (1.8) |  | 1.92 (1.4) | 3.0 (34) | 0.093t | 0.289 (−0.14–0.72) |
RSDI-Dissociation |  | 2.26 (1.8) |  | 1.96 (1.4) | 1.2 (34) | 0.26 | 0.195 (−0.13–0.52) |