Table 3 Baseline predictors of thrombotic risk in patients with LA: univariable and multivariable analyses

 Age at entry (per 5 years increase)

1.06

0.97-1.17

0.193

1.07

0.99-1.04

0.174

 Female gender

0.73

0.34-1.59

0.433

0.92

0.38-2.23

0.859

 BMI (per 5 kg/m² increase)

1.22

0.94-1.58

0.131

1.30

0.94-1.80

0.112

 Prior history of thrombosis

0.94

0.45-1.95

0.865

1.40

0.60-3.27

0.436

-Arterial

1.31

0.55-3.12

0.547

1.08

0.42-2.79

0.872

-Venous

0.73

0.37-1.46

0.374

1.06

0.51-2.20

0.870

-Arterial and venous

0.53

0.09-3.23

0.491

0.38

0.04-3.79

0.409

 Prior history of pregnancy complicationsa

0.97

0.39-2.40

0.954

0.53

0.19-1.48

0.225

 APS

0.75

0.36-1.58

0.448

0.89

0.39-2.00

0.772

 Family history of thrombosis

0.70

0.31-1.57

0.390

0.86

0.37-2.00

0.719

 Oral anticoagulation at baseline (VKA)

0.93

0.47-1.86

0.839

1.16

0.56-2.39

0.695

 Hypertension

1.28

0.60-2.75

0.525

0.79

0.25-2.53

0.697

 Diabetes

5.18

1.87-14.31

0.002

N/A

N/A

N/A

 Statin exposure

2.64

0.71-9.82

0.147

3.34

0.94-11.89

0.063

 Autoimmune rheumatic diseases^b

0.81

0.38-1.74

0.594

0.70

0.31-1.60

0.404

 Hereditary thrombophilia^c

1.22

0.60-2.46

0.586

1.23

0.59-2.55

0.580

 Active smoker at baseline

2.11

1.06-4.20

0.034

N/A

N/A

N/A

 aPTT-LA (per 10-s increase)

1.10

1.00-1.21

0.044

N/A

N/A

N/A

 aPTT ratio (per 1 multiple of the mean)

1.39

1.01-1.93

0.044

N/A

N/A

N/A

 aPTT or aPTT ratio >75th percentile^d

2.65

1.32-5.31

0.006

N/A

N/A

N/A

 aβ2-GPI IgM (per 1 logMPL increase)

1.12

0.87-1.46

0.377

1.00

0.75-1.33

0.993

 aβ2-GPI IgG (per 1 logGPL increase)

1.03

0.85-1.25

0.778

1.04

0.84-1.28

0.730

 aCL IgM (per 1 logMPL increase)

1.30

0.98-1.74

0.068

1.08

0.76-1.53

0.665

 aCL IgG (per 1 logGPL increase)

1.10

0.87-1.39

0.436

1.03

0.80-1.33

0.804

 LA alone

0.77

0.35-1.71

0.528

0.91

0.41-2.02

0.825

 LA + aβ2-GPI

1.33

0.60-2.95

0.476

1.14

0.51-2.53

0.746

 LA + aCL

1.42

0.71-2.82

0.323

1.16

0.56-2.42

0.684

 Triple positivity (ISTH cut-off)^e

1.53

0.77-3.04

0.226

1.22

0.58-2.54

0.598

 Triple positivity (Padova cut-off)^e

1.37

0.67-2.84

0.390

1.00

0.45-2.23

0.998

 Triple positivity (local cut-off)^e

1.21

0.59-2.51

0.603

0.91

0.42-1.99

0.812

 Domain I β2-GPI (per 1000 CU increase)

0.93

0.65-1.34

0.711

0.82

0.43-1.56

0.546

 Anti-protein Z IgM (per 10 units increase)

1.00

0.58-1.72

0.999

0.75

0.43-1.30

0.301

 Anti-protein Z IgG (per 10 units increase)

1.01

0.74-1.38

0.931

0.90

0.67-1.20

0.457

 Antiprothrombin IgM

0.98

0.87-1.10

0.747

0.98

0.94-1.01

0.163

 Antiprothrombin IgG

0.99

0.96-1.01

0.373

1.00

0.99-1.00

0.340

 Annexin A5 ratio (per 50% increase)

0.83

0.56-1.23

0.347

0.92

0.55-1.53

0.734

 C-reactive protein (per 5 mg/dL increase)

1.04

0.68-1.57

0.863

0.95

0.63-1.42

0.792

 Triglycerides (per 100 mg/dL increase)^f

1.32

0.86-2.01

0.201

1.19

0.96-1.47

0.121

 Cholesterol (per 100 mg/dL increase)

1.22

0.58-2.58

0.604

1.31

0.59-2.92

0.513

 HDL/LDL ratio (per 1 unit increase)

0.99

0.82-1.20

0.937

1.04

0.89-1.21

0.601

 Homocysteine (per 5 μmol/L increase)^f

1.25

0.81-1.93

0.316

1.03

0.94-1.12

0.571

 Fibrinogen (per 100 mg/dL increase)

1.15

0.80-1.66

0.440

1.23

0.86-1.77

0.253