Metabolomics approaches in pancreatic adenocarcinoma: tumor metabolism profiling predicts clinical outcome of patients

Table 2 Comparison between PP and PA (both without neoadjuvant chemotherapy)

Metabolite	No neoadjuvant chemotherapy	Mean (nmol/mg)	p value
Ascorbate	PP	0.3488 ± 0.2191	0.4454
Ascorbate	PA	0.3988 ± 0.2221	0.4454
Aspartic acid	PP	0.7577 ± 0.3284	0.2926
Aspartic acid	PA	0.6229 ± 0.2255	0.2926
Choline	PP	1.5580 ± 0.5921	0.0014
Choline	PA	0.8849 ± 0.3887	0.0014
Creatine	PP	1.7371 ± 0.9568	0.5047
Creatine	PA	1.3561 ± 0.5057	0.5047
Ethanolamine	PP	0.9314 ± 0.4502	0.0226
Ethanolamine	PA	0.6188 ± 0.2620	0.0226
Glutamate	PP	2.9830 ± 0.8698	0.1114
Glutamate	PA	2.4650 ± 0.7699	0.1114
Glycerol	PP	8.1840 ± 7.3988	0.0037
Glycerol	PA	2.2750 ± 1.1994	0.0037
Glycine	PP	6.0920 ± 5.0908	0.0005
Glycine	PA	2.2663 ± 0.8577	0.0005
Glycerophosphocholine	PP	2.4215 ± 2.6084	0.3516
Glycerophosphocholine	PA	1.0319 ± 0.5029	0.3516
Lactate	PP	11.0040 ± 2.4733	0.0006
Lactate	PA	16.1370 ± 4.7272	0.0006
Phosphorylcholine	PP	1.1696 ± 0.6396	0.5201
Phosphorylcholine	PA	0.9764 ± 0.5008	0.5201
Taurine	PP	2.9660 ± 1.9594	0.0021
Taurine	PA	4.4630 ± 1.4063	0.0021
Threonine	PP	1.1202 ± 0.2821	0.6512
Threonine	PA	1.1931 ± 0.4230	0.6512
Glutamine	PP	0.6855 ± 0.2518	0.6859
Glutamine	PA	0.6394 ± 0.2272	0.6859
Succinic acid	PP	0.3068 ± 0.2121	0.1786
Succinic acid	PA	0.1762 ± 0.0763	0.1786
Glucose	PP	1.2247 ± 0.6158	0.7937
Glucose	PA	1.3141 ± 1.1020	0.7937
Tyrosine	PP	0.0521 ± 0.0443	0.0583
Tyrosine	PA	0.0741 ± 0.0472	0.0583
Phenylalanine	PP	0.1449 ± 0.0771	0.0866
Phenylalanine	PA	0.0741 ± 0.0811	0.0866

Results of the Mann-Whitney U test. Metabolite differences between PP and PA, both without neoadjuvant chemotherapy (univariate analysis, nonparametric test)
p <0.05 are in boldface