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Table 4 Impact of neoadjuvant chemotherapy on pancreatic adenocarcinoma (PA)

From: Metabolomics approaches in pancreatic adenocarcinoma: tumor metabolism profiling predicts clinical outcome of patients

Metabolite Neoadjuvant chemotherapy Mean (nmol/mg) p value
Ascorbate No 0.3988 ± 0.2221 0.6648
Yes 0.4062 ± 0.2227
Aspartic acid No 0.6229 ± 0.2255 0.0017
Yes 0.9658 ± 0.6074
Choline No 0.8849 ± 0.3887 0.6600
Yes 0.9539 ± 0.4702
Creatine No 1.3561 ± 0.5057 0.4285
Yes 1.4464 ± 0.5971
Ethanolamine No 0.6148 ± 0.2620 0.1958
Yes 0.7511 ± 0.4177
Glutamate No 2.4650 ± 0.7699 0.0908
Yes 2.8070 ± 0.9767
Glycerol No 2.7550 ± 1.1994 0.1339
Yes 3.5300 ± 2.6914
Glycine No 2.2663 ± 0.8577 0.1265
Yes 2.9025 ± 1.8798
Glycerophosphocholine No 1.0319 ± 0.5029 0.7421
Yes 1.0810 ± 0.7982
Lactate No 16.1370 ± 4.7272 0.7969
Yes 15.9030 ± 5.3324
Phosphorylcholine No 0.9764 ± 0.5008 0.9092
Yes 0.9518 ± 0.4822
Taurine No 4.4630 ± 1.4062 0.8886
Yes 4.3490 ± 1.3425
Threonine No 1.1931 ± 0.4229 0.6273
Yes 1.2957 ± 0.6961
Glutamine No 0.6394 ± 0.2272 0.5864
Yes 0.6870 ± 0.2668
Succinic acid No 0.1762 ± 0.0763 0.4400
Yes 0.1866 ± 0.0739
Glucose No 1.3141 ± 1.1020 0.0813
Yes 2.3227 ± 2.7375
Tyrosine No 0.0730 ± 0.0493 0.3140
Yes 0.1097 ± 0.1479
Phenylalanine No 0.1789 ± 0.0811 0.1622
Yes 0.1097 ± 0.1958
  1. Results of the Mann-Whitney U test. Metabolite differences between PA without neoadjuvant chemotherapy and PA with neoadjuvant chemotherapy (univariate analysis, nonparametric test)